SAT406 Evaluation Of The Emotional And Cognitive Effects Of Hormone Therapy In Transgender Men And Women

Disclosure: I. Yaish: None. G. Keltch: None. Y. Greenman: None. K.M. Tordjman: None. Background:- Sex hormones have far-reaching effects on the brain, both emotionally and cognitively. - Varying levels of sex hormones are associated with altered emotional states and cognitive abilities. -No longitudinal study has assessed the impact of cross-sex hormone on these issues in young transgender people. Aim:•To prospectively evaluate the effect of gender-affirming hormonal therapy (GAHT) on cognition and emotional state in transgender men and women initiating therapy Subjects and Methods:- Transgender men (TM) aged 24.6±7.8 y (18-37), and 11 transgender women (TW) 27.3±9.4 (19-46).- Mood questionnaires (PHQ9 and GAD-7), and cognitive tests (short-term logical memory test, sub-tests of knowledge, forward and backward digit recall, number-coding and random learning from WAIS-III, a verbal fluency test and CTMT test) were administered prior to GAHT, and 3-6 months into treatment. - Scores were calculated for emotional stress, memory, attention, and executive functions. - Wilcoxon tests for paired samples assessed the impact of GAHT on these variables. Results - In TM, GAHT significantly improved executive functions but had no effect on memory, attention, and emotional stress. - In TW, GAHT significantly improved memory but had no effect on attention, executive functions, and emotional stress. - Despite a trend for improved emotional stress with GAHT in both groups, over this short study period, this was not significant. Conclusions:- - In keeping with the literature, this short preliminary study showed that estrogen contributes to memory, and testosterone to executive functions.-- This is the first time this has been shown in transgender individuals. -The lack of effect on emotional stress is probably due to the small sample size and short duration, larger studies should elucidate this point. Presentation: Saturday, June 17, 2023