Allosteric inhibition of the T cell receptor by a designed membrane ligand

The T cell receptor (TCR) is a complex molecular machine that directs the activation of T cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of investigation, the molecular mechanism of TCR activation is still controversial. One of the leading activation hypothese...

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Detalles Bibliográficos
Autores principales: Ye, Yujie, Morita, Shumpei, Chang, Justin J, Buckley, Patrick M, Wilhelm, Kiera B, DiMaio, Daniel, Groves, Jay T, Barrera, Francisco N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554751/
https://www.ncbi.nlm.nih.gov/pubmed/37796108
http://dx.doi.org/10.7554/eLife.82861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554751/
https://www.ncbi.nlm.nih.gov/pubmed/37796108
http://dx.doi.org/10.7554/eLife.82861

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