Cargando…
THU546 A Lasofoxifene/Elacestrant Hybrid Antiestrogen Shows Effective Anti-tumoral Activities In Y537S ESR1 Breast Cancer Xenografts
Disclosure: K.S. Young: None. G.R. Hancock: None. S. Kregel: None. S.W. Fanning: Advisory Board Member; Self; Olema Oncology. Grant Recipient; Self; Olema Oncology. In the United States, breast cancer is the second leading cause of cancer related deaths among women. Over 70 percent of these breast c...
Autores principales: | Young, Kristen S, Hancock, Govinda R, Kregel, Steven, Fanning, Sean William |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554897/ http://dx.doi.org/10.1210/jendso/bvad114.2172 |
Ejemplares similares
-
THU554 Unconventional Estrogen Receptor Antagonists Reveal Cryptic Therapeutic Anti-breast Cancer Transcriptional Pathways
por: Hancock, Govinda, et al.
Publicado: (2023) -
THU537 A Case Of Aggressive NET With Extensive Bone Marrow Metastasis Presenting With Hypercalcemia
por: Kela, Genevieve, et al.
Publicado: (2023) -
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells
por: Hosfield, David J, et al.
Publicado: (2022) -
SUN-006 Lasofoxifene Achieves Potent Anti-Tumor Activity in Hormone-Resistant Breast Tumors by Maintaining High Affinity Binding for Y537S ERα
por: Fanning, Sean, et al.
Publicado: (2019) -
Elacestrant: First Approval
por: Hoy, Sheridan M.
Publicado: (2023)