SAT410 Echocardiogram Analysis Of Transgender Women Amateur Athletes Undergoing Gender-affirming Hormone Therapy

Disclosure: L.A. Alvares: None. L.D. Santos: None. F.P. Nakamoto: None. R.E. Ferreira: None. R.C. Barbosa: None. M.V. Quaresma: None. B.M. Orozco: None. L.H. Falcão: None. L.S. Navarro: None. G.S. Navarro: None. F.M. Lima: None. [Editor1] Introduction: There are sex differences in the analysis of cardiac chambers by transthoracic echocardiogram. There are no data about it in transgender women (TW) undergoing gender-affirming hormone therapy (GAHT). Objective: To evaluate the heart thickness, dimensions and functionality of TW cardiac chambers. Method: A cross-sectional study was carried out with 8 TW (29 yo, range 27-36; BMI 24.1, (range 19.3-31.7), 11 cisgender women (CW) and 8 cisgender men (CM) matched by age and BMI. The height (cm) of TW was 172 (range 164-181), that of CW was 176±0.1 and that of CM was 185±5.6. All of them were amateur volleyball players. The TW had received estrogen for 3 (range 1-16) years. The volunteers were analyzed through a bidimensional echocardiogram with color Doppler flowmetry. Body composition was assessed by dual-energy X-ray absorptiometry. Results: The left atrium (LA) dimension (mm) was 32.0 (range 31.0-37.0) in TW, 33.0±2.6 in CW, and 35.3±2.2 in CM (TW vs. CW, p>0.05; TW vs. CM, p<0.05; CW vs. CM p>0.05). The septum (mm) in diastole: TW 8.0 (range 7.0-9.0), CW 7.6±0.5, and CM 9.0±1.1 (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p<0.05); Posterior wall (mm) in diastole: TW 8.0 (range 7.0-9.0), 7.5±0.7 in CW, and 9.0±1.0 in CM (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p<0.05); The left ventricular diastolic diameter (mm) was 48.0 (range 44.0-52) in TW, 49.4±4.1 in CW, and 52.3±2.3 in CM (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p>0.05), and systolic diameter (mm) was 30.7 (range 27-34) in TW, 31.6±2.9 in CW, and 34.3±2.5 in CM (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p>0.05). The ejection fraction (%) was 61 (range 40-68) in TW, 66±0.03 in CW, and 67±0.13 in CM (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p>0.05). Spearman correlations: ventricular septum vs. left ventricle posterior wall: TW (p>0.05; r=0.72); CW (p<0.05; r=0.976); CM (p<0.05; r=0.873); diastolic LV internal dimension diameter with systolic LV internal dimension: TW: r=0.916 (p>0.05); CW: r=0.867 (p<0.05); and CM: r=0.836 (p<0.05). The lean corporal mass (kg) was 54.4 (range 44.3-66.9) in TW, 51.9±8.1 in CW, and 67.5±6.3 in CM (TW vs. CW, p>0.05; TW vs. CM, p<0.05; CW vs. CM p<0.05). Discussion: The heart thickness of TW cardiac chambers was reduced compared to that in CM but higher than that in CW, though there was no statistical significance in all these analyses, which may be a consequence of the small cohort. This pattern was also seen in the lean corporal mass. Lower compliance of the LV and the decrease in heart thickness do not seem to interfere with functionality. Conclusion: There seem to be peculiar aspects of heart thickness and dimensions in TW undergoing GAHT cardiac chambers that should be assessed in depth. Presentation: Saturday, June 17, 2023