FRI541 The Epidemiology Of Thyroid Eye Disease In Olmsted County, Minnesota

Disclosure: K.N. Rachmasari: None. P. Thapa: None. D. Sighoko: Employee; Self; Horizon Therapeutics. L. Abdul Jabbar: None. M.N. Stan: None. Objective: To describe the epidemiology of Thyroid Eye Disease (TED). Methods: A population-based cohort of all Olmsted County, Minnesota, residents who had newly diagnosed TED between April 3, 2002, and December 31, 2021, was identified through the medical diagnostic index of the Rochester Epidemiology Project. Individuals aged 18 years and older were included. Incidence rates and point prevalence were calculated. Results: We identified 137 incident patients, of whom 124 (90.5%) were female (p < 0.0001). The overall incidence was 6.24 cases/100,000 person-years in Olmsted County, corresponding to 6.25 cases/100,000 person-years for the US population (age and sex adjusted incidence). Women had higher incidence (10.94 cases/ 100,000 person-years) compared to men (1.22 cases/100,000 person-years). The distribution of incidence rates by ten-year age groups demonstrated peak incidence rates in the age groups 70 to 79 years (17.94 cases/100,000 person-years for women compared with 4.04 cases for men). The majority of cases (77/137) occurred between 50-79 years of age. No clear trend was identified for the yearly incidence between 2002 and 2021. The overall estimated point prevalence per 100,000 was 65.6 (95% CI, 57.8 – 72.9). Prevalence was 117.6 (95% CI, 96.5 – 141.4) for females and 11.2 (95% CI, 5.1 – 21.2) for males (p < 0.0001). Conclusions: Incidence rates for TED remained stable and significant over the last 2 decades. Majority of disease burden is present after the age of 50 with the peak between 70-79 years, a decade later than in the previous study from our population (1). Based on reported incidence and prevalence of Graves’ disease (2), our data indicates that TED continues to affect about 20-30% of that population and appropriate resources should be devoted to furthering education, management, and research into this condition. References: 1. Bartley GB, Fatourechi V, Kadrmas EF, et al. The incidence of Graves' ophthalmopathy in Olmsted County, Minnesota. Am J Ophthalmol 1995;120(4):511-7, doi:10.1016/s0002-9394(14)72666-2 2. Hussain YS, Hookham JC, Allahabadia A, et al. Epidemiology, management and outcomes of Graves' disease-real life data. Endocrine 2017;56(3):568-578, doi:10.1007/s12020-017-1306-5 Presentation: Friday, June 16, 2023