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Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder
OBJECTIVE: Attention deficit/hyperactivity disorder (ADHD), whose definition, diagnosis and treatment has been the subject of debate in the scientific community for a long time, is the most common neurobehavioral disorder in childhood. There are many studies on the pathophysiology of attention defic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555513/ https://www.ncbi.nlm.nih.gov/pubmed/37794671 http://dx.doi.org/10.30773/pi.2023.0162 |
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author | Karabulut, Muhammed Yıldırım, Kübra |
author_facet | Karabulut, Muhammed Yıldırım, Kübra |
author_sort | Karabulut, Muhammed |
collection | PubMed |
description | OBJECTIVE: Attention deficit/hyperactivity disorder (ADHD), whose definition, diagnosis and treatment has been the subject of debate in the scientific community for a long time, is the most common neurobehavioral disorder in childhood. There are many studies on the pathophysiology of attention deficit. However, there is no study in the literature based on direct or indirect measurement of cerebral venous circulation in ADHD, and the effect of methylphenidate (MPH) treatment on cerebral venous circulation. Therefore, it was aimed to noninvasively measure superior vena cava (SVC) flow, which is an indirect indicator of cerebral venous flow, by transthoracic echocardiography in patients with ADHD. METHODS: In the study, 44 healthy children, and 40 ADHD patients who were planned to start on osmotic-release oral system (OROS)-MPH were included. SVC flows were measured in healthy children and before and after drug therapy of ADHD patients. RESULTS: SVC flow was found to be higher in ADHD patients compared to healthy children. A significant decrease was found in SVC flow of ADHD patients after OROS-MPH treatment. There was no decrease in SVC flow of patients who did not respond adequately to MPH treatment. CONCLUSION: This first study of SVC flow in children with ADHD showed that ADHD was associated with increased SVC flow and MPH treatment had a reducing effect on this increased SVC flow. We believe that noninvasive, easily measurable, and reproducible SVC flow may be a new focus of interest for future comprehensive studies as a biomarker to support clinical evaluation in the diagnosis and treatment follow-up of ADHD patients. |
format | Online Article Text |
id | pubmed-10555513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-105555132023-10-06 Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder Karabulut, Muhammed Yıldırım, Kübra Psychiatry Investig Original Article OBJECTIVE: Attention deficit/hyperactivity disorder (ADHD), whose definition, diagnosis and treatment has been the subject of debate in the scientific community for a long time, is the most common neurobehavioral disorder in childhood. There are many studies on the pathophysiology of attention deficit. However, there is no study in the literature based on direct or indirect measurement of cerebral venous circulation in ADHD, and the effect of methylphenidate (MPH) treatment on cerebral venous circulation. Therefore, it was aimed to noninvasively measure superior vena cava (SVC) flow, which is an indirect indicator of cerebral venous flow, by transthoracic echocardiography in patients with ADHD. METHODS: In the study, 44 healthy children, and 40 ADHD patients who were planned to start on osmotic-release oral system (OROS)-MPH were included. SVC flows were measured in healthy children and before and after drug therapy of ADHD patients. RESULTS: SVC flow was found to be higher in ADHD patients compared to healthy children. A significant decrease was found in SVC flow of ADHD patients after OROS-MPH treatment. There was no decrease in SVC flow of patients who did not respond adequately to MPH treatment. CONCLUSION: This first study of SVC flow in children with ADHD showed that ADHD was associated with increased SVC flow and MPH treatment had a reducing effect on this increased SVC flow. We believe that noninvasive, easily measurable, and reproducible SVC flow may be a new focus of interest for future comprehensive studies as a biomarker to support clinical evaluation in the diagnosis and treatment follow-up of ADHD patients. Korean Neuropsychiatric Association 2023-09 2023-09-19 /pmc/articles/PMC10555513/ /pubmed/37794671 http://dx.doi.org/10.30773/pi.2023.0162 Text en Copyright © 2023 Korean Neuropsychiatric Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Karabulut, Muhammed Yıldırım, Kübra Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title | Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title_full | Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title_fullStr | Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title_full_unstemmed | Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title_short | Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder |
title_sort | superior vena cava flow in children with attention deficit hyperactivity disorder |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555513/ https://www.ncbi.nlm.nih.gov/pubmed/37794671 http://dx.doi.org/10.30773/pi.2023.0162 |
work_keys_str_mv | AT karabulutmuhammed superiorvenacavaflowinchildrenwithattentiondeficithyperactivitydisorder AT yıldırımkubra superiorvenacavaflowinchildrenwithattentiondeficithyperactivitydisorder |