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Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease

BACKGROUND: In patients with chronic obstructive pulmonary disease (COPD), decreased muscle mass is a frequently encountered comorbidity in clinical practice. However, the evaluation of muscle mass in patients with COPD in real-world practice is rare. METHODS: We retrospectively reviewed the electro...

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Autores principales: Choi, Yong Jun, Park, Hye Jung, Cho, Jae Hwa, Byun, Min Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555524/
https://www.ncbi.nlm.nih.gov/pubmed/37582676
http://dx.doi.org/10.4046/trd.2023.0008
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author Choi, Yong Jun
Park, Hye Jung
Cho, Jae Hwa
Byun, Min Kwang
author_facet Choi, Yong Jun
Park, Hye Jung
Cho, Jae Hwa
Byun, Min Kwang
author_sort Choi, Yong Jun
collection PubMed
description BACKGROUND: In patients with chronic obstructive pulmonary disease (COPD), decreased muscle mass is a frequently encountered comorbidity in clinical practice. However, the evaluation of muscle mass in patients with COPD in real-world practice is rare. METHODS: We retrospectively reviewed the electronic medical records of all patients with COPD who underwent bioelectrical impedance analysis at least once between January 2011 and December 2021 in three hospitals. Then, we analyzed the performance rate of muscle mass measurement in the patients and the correlation between muscle mass, clinical parameters, and COPD prognosis. RESULTS: Among the 24,502 patients with COPD, only 270 (1.1%) underwent muscle mass measurements. The total skeletal muscle mass index was significantly correlated with albumin, alanine transaminase, and creatinine to cystatin C ratio in patients with COPD (r=0.1614, p=0.011; r=0.2112, p=0.001; and r=0.3671, p=0.001, respectively). Acute exacerbation of COPD (AE COPD) was significantly correlated with muscle mass, especially the truncal skeletal muscle mass index (TSMI) in males (r=–0.196, p=0.007). In the multivariate analysis, TSMI and cystatin C were significant risk factors for AE COPD (hazard ratio, 0.200 [95% confidence interval, CI, 0.048 to 0.838] and 4.990 [95% CI, 1.070 to 23.278], respectively). CONCLUSION: Low muscle mass negatively affects the clinical outcomes in patients with COPD. Despite its clinical significance, muscle mass measurement is performed in a small proportion of patients with COPD. Therefore, protocols and guidelines for the screening of sarcopenia in patients with COPD should be established.
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spelling pubmed-105555242023-10-07 Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease Choi, Yong Jun Park, Hye Jung Cho, Jae Hwa Byun, Min Kwang Tuberc Respir Dis (Seoul) Original Article BACKGROUND: In patients with chronic obstructive pulmonary disease (COPD), decreased muscle mass is a frequently encountered comorbidity in clinical practice. However, the evaluation of muscle mass in patients with COPD in real-world practice is rare. METHODS: We retrospectively reviewed the electronic medical records of all patients with COPD who underwent bioelectrical impedance analysis at least once between January 2011 and December 2021 in three hospitals. Then, we analyzed the performance rate of muscle mass measurement in the patients and the correlation between muscle mass, clinical parameters, and COPD prognosis. RESULTS: Among the 24,502 patients with COPD, only 270 (1.1%) underwent muscle mass measurements. The total skeletal muscle mass index was significantly correlated with albumin, alanine transaminase, and creatinine to cystatin C ratio in patients with COPD (r=0.1614, p=0.011; r=0.2112, p=0.001; and r=0.3671, p=0.001, respectively). Acute exacerbation of COPD (AE COPD) was significantly correlated with muscle mass, especially the truncal skeletal muscle mass index (TSMI) in males (r=–0.196, p=0.007). In the multivariate analysis, TSMI and cystatin C were significant risk factors for AE COPD (hazard ratio, 0.200 [95% confidence interval, CI, 0.048 to 0.838] and 4.990 [95% CI, 1.070 to 23.278], respectively). CONCLUSION: Low muscle mass negatively affects the clinical outcomes in patients with COPD. Despite its clinical significance, muscle mass measurement is performed in a small proportion of patients with COPD. Therefore, protocols and guidelines for the screening of sarcopenia in patients with COPD should be established. The Korean Academy of Tuberculosis and Respiratory Diseases 2023-10 2023-08-11 /pmc/articles/PMC10555524/ /pubmed/37582676 http://dx.doi.org/10.4046/trd.2023.0008 Text en Copyright © 2023 The Korean Academy of Tuberculosis and Respiratory Diseases https://creativecommons.org/licenses/by-nc/4.0/It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ).
spellingShingle Original Article
Choi, Yong Jun
Park, Hye Jung
Cho, Jae Hwa
Byun, Min Kwang
Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title_full Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title_fullStr Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title_short Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease
title_sort low skeletal muscle mass and clinical outcomes in chronic obstructive pulmonary disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555524/
https://www.ncbi.nlm.nih.gov/pubmed/37582676
http://dx.doi.org/10.4046/trd.2023.0008
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