THU179 Lifestyle Practices Elicited Different Responses To Growth Velocity Among Adolescents Depending On Different Levels Of Genetic Risk Score

Disclosure: N. Nguyen: None. H. Fan: None. Y. Chen: None. Context: The evidence regarding effects of different lifestyle pratices, such as sun bathing, exercising, rope jumping, sleep duration, and milk intake, on growth velocity remain controversial and the influence of genetically determined characteristics on this association is less studied. Objective: To assess the impacts of different lifestyle pratices on annualized growth velocity and evaluate the role of several combined height-related alleles, mirrorred by the genetic risk score, on the association between lifestyle practices and growth among adolescents. Design: Prospective cohort study (mean follow-up duration: 2 years) Setting: Primary Care Participants: The Taiwan Puberty Longitudinal Study cohort, including male and female adolescent aged 6-17 (N = 1036) who were examined at both baseline and follow-up clinic visits. Main Outcome Measures: The effects of regular lifestyle practices (sun soaking, exercise habit, jumping rope, milk intake and sleep duration) on changes in height measurements. Participants will be stratified by either low or high genetic risk score. Results: Among lifestyle practices, sleep duration was significantly associated with growth velocity. Sleeping hours ranging between 7-8 hours per night were linked with a greatest growth. This relation was mainly driven by differences in males and was more obvious during Tanner’s stage II-III. The positive association between sleep duration and growth velocity was driven by significance in participants with low genetic risk score but not in those with high genetic risk score. Meanwhile, milk intake of greater than or equal to one cup per day had a modest effect on height velocity in male during Tanner’s stage I. Conclusions: Sleep duration was associated with growth velocity, in which 7-8 hours per night was optimal. The benefit of adequate sleep was greater in individuals having low genetic risk score. Milk intake may have modest effect on growth velocity. Presentation: Thursday, June 15, 2023