THU428 Association Of Bone Turnover Markers Monitoring With Osteoporosis Medication Adherence In Korea: A Nationwide Cohort Study

Disclosure: S. Ahn: None. S. Park: None. M. Kwak: None. S. Kim: None. T. Kim: None. H. Kim: None. S. Hong: None. Objective: Bone turnover markers (BTMs) are non-invasive and useful biomarkers for predicting the risk of fractures and monitoring the adherence and response to medical treatment in patients with osteoporosis. However, the contribution of BTMs in the improvement of osteoporosis medication adherence has not been well studied. Therefore, we investigated the association of BTMs monitoring with medication adherence in Korean osteoporosis patients. Methods: We used data from the Korean National Health Insurance Service. Among 1,440,538 osteoporosis patients ≥50 years who started with medical treatment during 2010-2014, we selected 118,598 patients who monitored BTMs at least once during 2 years of follow up (BTM group) and 362,794 age-, sex-, and medication initiation year-matched controls who never measured BTMs (NO-BTM group). Adherence to medical treatment was defined as medication possession ratio ≥80%. Multivariable logistic regression analysis was used to determine the association of BTMs monitoring with adherence at 2 year follow up. Results: Among BTM group, 92.5% and 87.1% patients monitored bone resorption or formation markers at least once during 2 years of follow up, respectively. However, only 36.0% of patients monitored BTMs more than twice. MPRs at 2 year follow up were higher in BTM group than in NO-BTM group (41.4% vs. 26.5%, P<0.001). Among BTM group, MPRs were higher in patients who monitored bone resorption markers than in patients who never monitored them (41.7% vs. 36.1%, P<0.001) and in patients who monitored BTMs more than twice than in patients who monitored them only once (55.6% vs. 32.9%, P<0.001). BTMs monitoring showed positive association with MPRs at 2 year follow up (β = 3.055, SE = 0.137, P<0.001) after adjusting for confounders. BTMs monitoring was associated with increased OR (1.17, 95% CI 1.15-1.20, P<0.001) for better adherence to medical treatment at 2 year follow up after adjusting for confounders. Conclusion: In this retrospective study, monitoring of BTMs was associated with better adherence to medical treatment in Korean patients with osteoporosis. Presentation: Thursday, June 15, 2023