The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-characterized, the deubiquitylase that reverses these reactions remains unclear. Herein, we identify...

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Detalles Bibliográficos
Autores principales: Ng, Victoria H., Spencer, Zachary, Neitzel, Leif R., Nayak, Anmada, Loberg, Matthew A., Shen, Chen, Kassel, Sara N., Kroh, Heather K., An, Zhenyi, Anthony, Christin C., Bryant, Jamal M., Lawson, Amanda, Goldsmith, Lily, Benchabane, Hassina, Hansen, Amanda G., Li, Jingjing, D’Souza, Starina, Lebensohn, Andres M., Rohatgi, Rajat, Weiss, William A., Weiss, Vivian L., Williams, Charles, Hong, Charles C., Robbins, David J., Ahmed, Yashi, Lee, Ethan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556042/
https://www.ncbi.nlm.nih.gov/pubmed/37798301
http://dx.doi.org/10.1038/s41467-023-41836-z

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