The Role of Advanced Parental Age in Reproductive Genetics

The increase of parental reproductive age is a worldwide trend in modern society in recent decades. In general, older parents have a significant impact on reproductive genetics and the health of offspring. In particular, advanced parental age contributes to the increase in the risk of adverse neurod...

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Detalles Bibliográficos
Autores principales: Chu, Boling, Liu, Zhi, Liu, Yihong, Jiang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556127/
https://www.ncbi.nlm.nih.gov/pubmed/37171772
http://dx.doi.org/10.1007/s43032-023-01256-2
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author Chu, Boling
Liu, Zhi
Liu, Yihong
Jiang, Hui
author_facet Chu, Boling
Liu, Zhi
Liu, Yihong
Jiang, Hui
author_sort Chu, Boling
collection PubMed
description The increase of parental reproductive age is a worldwide trend in modern society in recent decades. In general, older parents have a significant impact on reproductive genetics and the health of offspring. In particular, advanced parental age contributes to the increase in the risk of adverse neurodevelopmental outcomes in offspring. However, it is currently under debate how and to what extent the health of future generations was affected by the parental age. In this review, we aimed to (i) provide an overview of the effects of age on the fertility and biology of the reproductive organs of the parents, (ii) highlight the candidate biological mechanisms underlying reproductive genetic alterations, and (iii) discuss the relevance of the effect of parental age on offspring between animal experiment and clinical observation. In addition, we think that the impact of environmental factors on cognitive and emotional development of older offspring will be an interesting direction.
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spelling pubmed-105561272023-10-07 The Role of Advanced Parental Age in Reproductive Genetics Chu, Boling Liu, Zhi Liu, Yihong Jiang, Hui Reprod Sci Review The increase of parental reproductive age is a worldwide trend in modern society in recent decades. In general, older parents have a significant impact on reproductive genetics and the health of offspring. In particular, advanced parental age contributes to the increase in the risk of adverse neurodevelopmental outcomes in offspring. However, it is currently under debate how and to what extent the health of future generations was affected by the parental age. In this review, we aimed to (i) provide an overview of the effects of age on the fertility and biology of the reproductive organs of the parents, (ii) highlight the candidate biological mechanisms underlying reproductive genetic alterations, and (iii) discuss the relevance of the effect of parental age on offspring between animal experiment and clinical observation. In addition, we think that the impact of environmental factors on cognitive and emotional development of older offspring will be an interesting direction. Springer International Publishing 2023-05-12 /pmc/articles/PMC10556127/ /pubmed/37171772 http://dx.doi.org/10.1007/s43032-023-01256-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Chu, Boling
Liu, Zhi
Liu, Yihong
Jiang, Hui
The Role of Advanced Parental Age in Reproductive Genetics
title The Role of Advanced Parental Age in Reproductive Genetics
title_full The Role of Advanced Parental Age in Reproductive Genetics
title_fullStr The Role of Advanced Parental Age in Reproductive Genetics
title_full_unstemmed The Role of Advanced Parental Age in Reproductive Genetics
title_short The Role of Advanced Parental Age in Reproductive Genetics
title_sort role of advanced parental age in reproductive genetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556127/
https://www.ncbi.nlm.nih.gov/pubmed/37171772
http://dx.doi.org/10.1007/s43032-023-01256-2
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