Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes

Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA. Here, we decipher how Rad52 functions using single-particle cryo-electron microscopy and biophysical approaches. We rep...

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Detalles Bibliográficos
Autores principales: Deveryshetty, Jaigeeth, Chadda, Rahul, Mattice, Jenna R., Karunakaran, Simrithaa, Rau, Michael J., Basore, Katherine, Pokhrel, Nilisha, Englander, Noah, Fitzpatrick, James A. J., Bothner, Brian, Antony, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556141/
https://www.ncbi.nlm.nih.gov/pubmed/37798272
http://dx.doi.org/10.1038/s41467-023-41993-1

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