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Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults

BACKGROUND: Adherence to the diabetes risk reduction diet (DRRD) may potentially reduce the risk of developing head and neck cancer (HNC) as the diet includes fruits and limits red and processed meats, known risk factors for HNC. However, there is currently no epidemiological research to investigate...

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Autores principales: Wu, Xia, Peng, Linglong, Luo, Haoyun, Xu, Zhiquan, Wang, Jijian, Gu, Haitao, Wang, Yaxu, Xiao, Yi, Zhang, Chaohua, Xiang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556244/
https://www.ncbi.nlm.nih.gov/pubmed/37810918
http://dx.doi.org/10.3389/fnut.2023.1218632
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author Wu, Xia
Peng, Linglong
Luo, Haoyun
Xu, Zhiquan
Wang, Jijian
Gu, Haitao
Wang, Yaxu
Xiao, Yi
Zhang, Chaohua
Xiang, Ling
author_facet Wu, Xia
Peng, Linglong
Luo, Haoyun
Xu, Zhiquan
Wang, Jijian
Gu, Haitao
Wang, Yaxu
Xiao, Yi
Zhang, Chaohua
Xiang, Ling
author_sort Wu, Xia
collection PubMed
description BACKGROUND: Adherence to the diabetes risk reduction diet (DRRD) may potentially reduce the risk of developing head and neck cancer (HNC) as the diet includes fruits and limits red and processed meats, known risk factors for HNC. However, there is currently no epidemiological research to investigate this potential association. METHODS: The present study utilized data on demographics, lifestyles, medications, and diets of participants from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial to explore the potential association between adherence to DRRD and the risk of HNC. We used a DRRD score to evaluate adherence to the dietary pattern and employed Cox regression analysis to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for HNC risk. Several subgroup analyses were carried out to identify potential effect modifiers, and multiple sensitivity analyses were performed to evaluate the stability of the correlation. The nine components of the DRRD was assessed separately for its association with the risk of HNC. RESULTS: During a mean follow up of 8.84 years, 279 cases of HNC were observed. DDRD score was found to be inversely associated with the risk of HNC (HR (Q4 vs. Q1): 0.582; 95% CI: 0.396, 0.856; p = 0.005 for trend) in a linear dose–response manner (p = 0.211 for non-linearity). Subgroup analysis indicated this inverse correlation was more pronounced among participants who had never smoked (HR(Q4 vs. Q1): 0.193; 95% CI: 0.073, 0.511; p < 0.001 for trend) compared to current or former smokers (p = 0.044 for interaction). The primary association of DDRD and HNC risk remained robust after several sensitivity analyses. Regarding the individual components of DRRD, an inverse association was also observed between the risk of HNC and increased intake of cereal fiber and whole fruit (all p < 0.05 for trend). CONCLUSION: Our findings provide evidence that following the DRRD pattern may reduce the risk of NHC, especially for non-smokers.
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spelling pubmed-105562442023-10-07 Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults Wu, Xia Peng, Linglong Luo, Haoyun Xu, Zhiquan Wang, Jijian Gu, Haitao Wang, Yaxu Xiao, Yi Zhang, Chaohua Xiang, Ling Front Nutr Nutrition BACKGROUND: Adherence to the diabetes risk reduction diet (DRRD) may potentially reduce the risk of developing head and neck cancer (HNC) as the diet includes fruits and limits red and processed meats, known risk factors for HNC. However, there is currently no epidemiological research to investigate this potential association. METHODS: The present study utilized data on demographics, lifestyles, medications, and diets of participants from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial to explore the potential association between adherence to DRRD and the risk of HNC. We used a DRRD score to evaluate adherence to the dietary pattern and employed Cox regression analysis to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for HNC risk. Several subgroup analyses were carried out to identify potential effect modifiers, and multiple sensitivity analyses were performed to evaluate the stability of the correlation. The nine components of the DRRD was assessed separately for its association with the risk of HNC. RESULTS: During a mean follow up of 8.84 years, 279 cases of HNC were observed. DDRD score was found to be inversely associated with the risk of HNC (HR (Q4 vs. Q1): 0.582; 95% CI: 0.396, 0.856; p = 0.005 for trend) in a linear dose–response manner (p = 0.211 for non-linearity). Subgroup analysis indicated this inverse correlation was more pronounced among participants who had never smoked (HR(Q4 vs. Q1): 0.193; 95% CI: 0.073, 0.511; p < 0.001 for trend) compared to current or former smokers (p = 0.044 for interaction). The primary association of DDRD and HNC risk remained robust after several sensitivity analyses. Regarding the individual components of DRRD, an inverse association was also observed between the risk of HNC and increased intake of cereal fiber and whole fruit (all p < 0.05 for trend). CONCLUSION: Our findings provide evidence that following the DRRD pattern may reduce the risk of NHC, especially for non-smokers. Frontiers Media S.A. 2023-09-22 /pmc/articles/PMC10556244/ /pubmed/37810918 http://dx.doi.org/10.3389/fnut.2023.1218632 Text en Copyright © 2023 Wu, Peng, Luo, Xu, Wang, Gu, Wang, Xiao, Zhang and Xiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Wu, Xia
Peng, Linglong
Luo, Haoyun
Xu, Zhiquan
Wang, Jijian
Gu, Haitao
Wang, Yaxu
Xiao, Yi
Zhang, Chaohua
Xiang, Ling
Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title_full Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title_fullStr Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title_full_unstemmed Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title_short Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults
title_sort adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 american adults
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556244/
https://www.ncbi.nlm.nih.gov/pubmed/37810918
http://dx.doi.org/10.3389/fnut.2023.1218632
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