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Multiple regions of sensorimotor cortex encode bite force and gape

The precise control of bite force and gape is vital for safe and effective breakdown and manipulation of food inside the oral cavity during feeding. Yet, the role of the orofacial sensorimotor cortex (OSMcx) in the control of bite force and gape is still largely unknown. The aim of this study was to...

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Autores principales: Arce-McShane, Fritzie I., Sessle, Barry J., Ram, Yasheshvini, Ross, Callum F., Hatsopoulos, Nicholas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556252/
https://www.ncbi.nlm.nih.gov/pubmed/37808467
http://dx.doi.org/10.3389/fnsys.2023.1213279
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author Arce-McShane, Fritzie I.
Sessle, Barry J.
Ram, Yasheshvini
Ross, Callum F.
Hatsopoulos, Nicholas G.
author_facet Arce-McShane, Fritzie I.
Sessle, Barry J.
Ram, Yasheshvini
Ross, Callum F.
Hatsopoulos, Nicholas G.
author_sort Arce-McShane, Fritzie I.
collection PubMed
description The precise control of bite force and gape is vital for safe and effective breakdown and manipulation of food inside the oral cavity during feeding. Yet, the role of the orofacial sensorimotor cortex (OSMcx) in the control of bite force and gape is still largely unknown. The aim of this study was to elucidate how individual neurons and populations of neurons in multiple regions of OSMcx differentially encode bite force and static gape when subjects (Macaca mulatta) generated different levels of bite force at varying gapes. We examined neuronal activity recorded simultaneously from three microelectrode arrays implanted chronically in the primary motor (MIo), primary somatosensory (SIo), and cortical masticatory (CMA) areas of OSMcx. We used generalized linear models to evaluate encoding properties of individual neurons and utilized dimensionality reduction techniques to decompose population activity into components related to specific task parameters. Individual neurons encoded bite force more strongly than gape in all three OSMCx areas although bite force was a better predictor of spiking activity in MIo vs. SIo. Population activity differentiated between levels of bite force and gape while preserving task-independent temporal modulation across the behavioral trial. While activation patterns of neuronal populations were comparable across OSMCx areas, the total variance explained by task parameters was context-dependent and differed across areas. These findings suggest that the cortical control of static gape during biting may rely on computations at the population level whereas the strong encoding of bite force at the individual neuron level allows for the precise and rapid control of bite force.
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spelling pubmed-105562522023-10-07 Multiple regions of sensorimotor cortex encode bite force and gape Arce-McShane, Fritzie I. Sessle, Barry J. Ram, Yasheshvini Ross, Callum F. Hatsopoulos, Nicholas G. Front Syst Neurosci Neuroscience The precise control of bite force and gape is vital for safe and effective breakdown and manipulation of food inside the oral cavity during feeding. Yet, the role of the orofacial sensorimotor cortex (OSMcx) in the control of bite force and gape is still largely unknown. The aim of this study was to elucidate how individual neurons and populations of neurons in multiple regions of OSMcx differentially encode bite force and static gape when subjects (Macaca mulatta) generated different levels of bite force at varying gapes. We examined neuronal activity recorded simultaneously from three microelectrode arrays implanted chronically in the primary motor (MIo), primary somatosensory (SIo), and cortical masticatory (CMA) areas of OSMcx. We used generalized linear models to evaluate encoding properties of individual neurons and utilized dimensionality reduction techniques to decompose population activity into components related to specific task parameters. Individual neurons encoded bite force more strongly than gape in all three OSMCx areas although bite force was a better predictor of spiking activity in MIo vs. SIo. Population activity differentiated between levels of bite force and gape while preserving task-independent temporal modulation across the behavioral trial. While activation patterns of neuronal populations were comparable across OSMCx areas, the total variance explained by task parameters was context-dependent and differed across areas. These findings suggest that the cortical control of static gape during biting may rely on computations at the population level whereas the strong encoding of bite force at the individual neuron level allows for the precise and rapid control of bite force. Frontiers Media S.A. 2023-09-22 /pmc/articles/PMC10556252/ /pubmed/37808467 http://dx.doi.org/10.3389/fnsys.2023.1213279 Text en Copyright © 2023 Arce-McShane, Sessle, Ram, Ross and Hatsopoulos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Arce-McShane, Fritzie I.
Sessle, Barry J.
Ram, Yasheshvini
Ross, Callum F.
Hatsopoulos, Nicholas G.
Multiple regions of sensorimotor cortex encode bite force and gape
title Multiple regions of sensorimotor cortex encode bite force and gape
title_full Multiple regions of sensorimotor cortex encode bite force and gape
title_fullStr Multiple regions of sensorimotor cortex encode bite force and gape
title_full_unstemmed Multiple regions of sensorimotor cortex encode bite force and gape
title_short Multiple regions of sensorimotor cortex encode bite force and gape
title_sort multiple regions of sensorimotor cortex encode bite force and gape
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556252/
https://www.ncbi.nlm.nih.gov/pubmed/37808467
http://dx.doi.org/10.3389/fnsys.2023.1213279
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