Cargando…

Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?

PURPOSE: The overall incidence of central precocious puberty (CPP) has increased in recent decades, and brain magnetic resonance imaging (MRI) evaluations are recommended in cases of suspected brain lesions. This study aimed to investigate the prevalence of MRI abnormalities and to evaluate the need...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Ye Rim, Kim, Yu Jin, Oh, Kyeong Eun, Park, Gyu Hyun, Kang, Eungu, Nam, Hyo-Kyoung, Rhie, Young-Jun, Oh, Saelin, Lee, Kee-Hyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Pediatric Endocrinology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556448/
https://www.ncbi.nlm.nih.gov/pubmed/37798894
http://dx.doi.org/10.6065/apem.2244192.096
_version_ 1785116873322397696
author Oh, Ye Rim
Kim, Yu Jin
Oh, Kyeong Eun
Park, Gyu Hyun
Kang, Eungu
Nam, Hyo-Kyoung
Rhie, Young-Jun
Oh, Saelin
Lee, Kee-Hyoung
author_facet Oh, Ye Rim
Kim, Yu Jin
Oh, Kyeong Eun
Park, Gyu Hyun
Kang, Eungu
Nam, Hyo-Kyoung
Rhie, Young-Jun
Oh, Saelin
Lee, Kee-Hyoung
author_sort Oh, Ye Rim
collection PubMed
description PURPOSE: The overall incidence of central precocious puberty (CPP) has increased in recent decades, and brain magnetic resonance imaging (MRI) evaluations are recommended in cases of suspected brain lesions. This study aimed to investigate the prevalence of MRI abnormalities and to evaluate the need for routine brain MRI in patients with newly diagnosed CPP. METHODS: This retrospective study reviewed the data of patients newly diagnosed with CPP who underwent routine pituitary MRI at Korea University Anam Hospital from March 2020 to September 2021. A total of 199 girls and 24 boys was enrolled in this study. Positive MRI findings were categorized as abnormal pituitary, nonpituitary incidental, and pathological. In addition, we investigated the incidence of MRI abnormalities and evaluated their associations with clinical and biochemical factors. RESULTS: Positive brain MRI findings were observed in 84 patients (37.7%). Pituitary abnormalities were found in 54 patients (24.2%), with Rathke cleft cysts being the most common (16.1%). Incidental nonpituitary findings were observed in 29 patients (13.0%), while a pathological brain lesion (diagnosed as hypothalamic hamartoma) was observed in only 1 female patient (0.4%). No significant differences in sex or age were found in incidence of pituitary abnormalities or nonpituitary incidental findings. Compared with headache controls, significant associations were observed between abnormal pituitary findings on MRI and CPP (unadjusted odds ratio, 3.979; 95% confidence interval, 1.726–9.173). CONCLUSIONS: True pathological findings were rare, even though the prevalence of abnormalities on pituitary MRI in patients with CPP was relatively high. Considering its cost-effectiveness, MRI screenings should be carefully considered in patients with CPP.
format Online
Article
Text
id pubmed-10556448
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Korean Society of Pediatric Endocrinology
record_format MEDLINE/PubMed
spelling pubmed-105564482023-10-07 Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients? Oh, Ye Rim Kim, Yu Jin Oh, Kyeong Eun Park, Gyu Hyun Kang, Eungu Nam, Hyo-Kyoung Rhie, Young-Jun Oh, Saelin Lee, Kee-Hyoung Ann Pediatr Endocrinol Metab Original Article PURPOSE: The overall incidence of central precocious puberty (CPP) has increased in recent decades, and brain magnetic resonance imaging (MRI) evaluations are recommended in cases of suspected brain lesions. This study aimed to investigate the prevalence of MRI abnormalities and to evaluate the need for routine brain MRI in patients with newly diagnosed CPP. METHODS: This retrospective study reviewed the data of patients newly diagnosed with CPP who underwent routine pituitary MRI at Korea University Anam Hospital from March 2020 to September 2021. A total of 199 girls and 24 boys was enrolled in this study. Positive MRI findings were categorized as abnormal pituitary, nonpituitary incidental, and pathological. In addition, we investigated the incidence of MRI abnormalities and evaluated their associations with clinical and biochemical factors. RESULTS: Positive brain MRI findings were observed in 84 patients (37.7%). Pituitary abnormalities were found in 54 patients (24.2%), with Rathke cleft cysts being the most common (16.1%). Incidental nonpituitary findings were observed in 29 patients (13.0%), while a pathological brain lesion (diagnosed as hypothalamic hamartoma) was observed in only 1 female patient (0.4%). No significant differences in sex or age were found in incidence of pituitary abnormalities or nonpituitary incidental findings. Compared with headache controls, significant associations were observed between abnormal pituitary findings on MRI and CPP (unadjusted odds ratio, 3.979; 95% confidence interval, 1.726–9.173). CONCLUSIONS: True pathological findings were rare, even though the prevalence of abnormalities on pituitary MRI in patients with CPP was relatively high. Considering its cost-effectiveness, MRI screenings should be carefully considered in patients with CPP. Korean Society of Pediatric Endocrinology 2023-09 2023-09-19 /pmc/articles/PMC10556448/ /pubmed/37798894 http://dx.doi.org/10.6065/apem.2244192.096 Text en © 2023 Annals of Pediatric Endocrinology & Metabolism https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oh, Ye Rim
Kim, Yu Jin
Oh, Kyeong Eun
Park, Gyu Hyun
Kang, Eungu
Nam, Hyo-Kyoung
Rhie, Young-Jun
Oh, Saelin
Lee, Kee-Hyoung
Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title_full Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title_fullStr Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title_full_unstemmed Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title_short Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?
title_sort brain magnetic resonance imaging (mri) findings in central precocious puberty patients: is routine mri necessary for newly diagnosed patients?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556448/
https://www.ncbi.nlm.nih.gov/pubmed/37798894
http://dx.doi.org/10.6065/apem.2244192.096
work_keys_str_mv AT ohyerim brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT kimyujin brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT ohkyeongeun brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT parkgyuhyun brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT kangeungu brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT namhyokyoung brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT rhieyoungjun brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT ohsaelin brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients
AT leekeehyoung brainmagneticresonanceimagingmrifindingsincentralprecociouspubertypatientsisroutinemrinecessaryfornewlydiagnosedpatients