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Fluorescent reporter of Caenorhabditis elegans Parkin: Regulators of its abundance and role in autophagy-lysosomal dynamics

Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood. Here, we used protein interactor and genetic screens in Caenorhabditis elegans ( C. elegans)...

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Detalles Bibliográficos
Autores principales:	Vozdek, Roman, Wang, Bingying, Li, Kathy H., Pramstaller, Peter P., Hicks, Andrew A., Ma, Dengke K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556562/ https://www.ncbi.nlm.nih.gov/pubmed/37811477 http://dx.doi.org/10.12688/openreseurope.14235.2

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