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Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study
BACKGROUND & OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microR...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556652/ https://www.ncbi.nlm.nih.gov/pubmed/37810880 http://dx.doi.org/10.3389/fendo.2023.1230046 |
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author | Frías, Mario Corona-Mata, Diana Moyano, Jose M. Camacho-Espejo, Angela López-López, Pedro Caballero-Gómez, Javier Ruiz-Cáceres, Inmaculada Casares-Jiménez, María Pérez-Valero, Ignacio Rivero-Juárez, Antonio Rivero, Antonio |
author_facet | Frías, Mario Corona-Mata, Diana Moyano, Jose M. Camacho-Espejo, Angela López-López, Pedro Caballero-Gómez, Javier Ruiz-Cáceres, Inmaculada Casares-Jiménez, María Pérez-Valero, Ignacio Rivero-Juárez, Antonio Rivero, Antonio |
author_sort | Frías, Mario |
collection | PubMed |
description | BACKGROUND & OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD. METHODS: A discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen. RESULTS: Serum 2,083 simultaneous microRNA transcripts were analyzed using HTG technology and compared between cases and controls. Forty-five patients, 23 cases, and 22 controls were included in the study. In the analysis of the expression pattern of the 2,083 microRNAs, no differential expression patterns were found between both groups of patients included in the study. CONCLUSION: Analysis of the microRNA transcriptome profile of nonobese PLWH with severe NAFLD did not appear to differ from that of patients without NAFLD. Thus, microRNA might not serve as a proper biomarker for predicting severe NALFD in this population. |
format | Online Article Text |
id | pubmed-10556652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105566522023-10-07 Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study Frías, Mario Corona-Mata, Diana Moyano, Jose M. Camacho-Espejo, Angela López-López, Pedro Caballero-Gómez, Javier Ruiz-Cáceres, Inmaculada Casares-Jiménez, María Pérez-Valero, Ignacio Rivero-Juárez, Antonio Rivero, Antonio Front Endocrinol (Lausanne) Endocrinology BACKGROUND & OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD. METHODS: A discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen. RESULTS: Serum 2,083 simultaneous microRNA transcripts were analyzed using HTG technology and compared between cases and controls. Forty-five patients, 23 cases, and 22 controls were included in the study. In the analysis of the expression pattern of the 2,083 microRNAs, no differential expression patterns were found between both groups of patients included in the study. CONCLUSION: Analysis of the microRNA transcriptome profile of nonobese PLWH with severe NAFLD did not appear to differ from that of patients without NAFLD. Thus, microRNA might not serve as a proper biomarker for predicting severe NALFD in this population. Frontiers Media S.A. 2023-09-22 /pmc/articles/PMC10556652/ /pubmed/37810880 http://dx.doi.org/10.3389/fendo.2023.1230046 Text en Copyright © 2023 Frías, Corona-Mata, Moyano, Camacho-Espejo, López-López, Caballero-Gómez, Ruiz-Cáceres, Casares-Jiménez, Pérez-Valero, Rivero-Juárez and Rivero https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Frías, Mario Corona-Mata, Diana Moyano, Jose M. Camacho-Espejo, Angela López-López, Pedro Caballero-Gómez, Javier Ruiz-Cáceres, Inmaculada Casares-Jiménez, María Pérez-Valero, Ignacio Rivero-Juárez, Antonio Rivero, Antonio Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title | Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title_full | Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title_fullStr | Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title_full_unstemmed | Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title_short | Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study |
title_sort | lack of associations of micrornas with severe nafld in people living with hiv: discovery case-control study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556652/ https://www.ncbi.nlm.nih.gov/pubmed/37810880 http://dx.doi.org/10.3389/fendo.2023.1230046 |
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