SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cell proliferation

Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) is important for the expression of genes associated with oxidative stress. The levels of NRF2 are controlled by Kelch-like ECH-associated protein 1 (KEAP1)-dependent degradation. Although oxidative stress is known to suppress KEAP1 activity to stabi...

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Detalles Bibliográficos
Autores principales: Yang, Hao, Du, Yuzhang, Fei, Xuefeng, Huang, Shu, Yimiti, Maimaitiaili, Yang, Xiaobao, Ma, Junrui, Li, Shuhui, Tuoheniyazi, Huxidanmu, Zhao, Yanan, Gu, Zhidong, Xu, Dakang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556770/
https://www.ncbi.nlm.nih.gov/pubmed/37660919
http://dx.doi.org/10.1016/j.jbc.2023.105215

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