Binding of the nuclear ribonucleoprotein family member FUS to RNA prevents R-loop RNA:DNA hybrid structures

The protein FUS (FUSed in sarcoma) is a metazoan RNA-binding protein that influences RNA production by all three nuclear polymerases. FUS also binds nascent transcripts, RNA processing factors, RNA polymerases, and transcription machinery. Here, we explored the role of FUS binding interactions for a...

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Detalles Bibliográficos
Autores principales: Thompson, Valery F., Wieland, Daniel R., Mendoza-Leon, Vivian, Janis, Helen I., Lay, Michelle A., Harrell, Lucas M., Schwartz, Jacob C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556777/
https://www.ncbi.nlm.nih.gov/pubmed/37690693
http://dx.doi.org/10.1016/j.jbc.2023.105237

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