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Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study

OBJECTIVE: This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. METHODS: The experiment used 8 healthy por...

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Autores principales: Yajima, Shin, Zhu, Yuanjia, Stark, Charles J., Wilkerson, Robert J., Park, Matthew H., Stefan, Elde, Woo, Y. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556825/
https://www.ncbi.nlm.nih.gov/pubmed/37808060
http://dx.doi.org/10.1016/j.xjon.2023.04.011
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author Yajima, Shin
Zhu, Yuanjia
Stark, Charles J.
Wilkerson, Robert J.
Park, Matthew H.
Stefan, Elde
Woo, Y. Joseph
author_facet Yajima, Shin
Zhu, Yuanjia
Stark, Charles J.
Wilkerson, Robert J.
Park, Matthew H.
Stefan, Elde
Woo, Y. Joseph
author_sort Yajima, Shin
collection PubMed
description OBJECTIVE: This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. METHODS: The experiment used 8 healthy porcine mitral valves. Chordal forces were measured using fiber Bragg grating sensors on primary and secondary chordae from A2 segments. The anterior valve prolapse model was generated by excising 2 primary chordae at the A2 segment. Neochord repair was performed with 2 pairs of neochords. Varying neochord lengths simulated postrepair residual mitral regurgitation with regurgitant fraction at >30% (moderate), 10% to 30% (mild), and <10% (perfect repair). RESULTS: Regurgitant fractions of baseline, moderate, mild, and perfect repair were 4.7% ± 0.8%, 35.8% ± 2.1%, 19.8% ± 2.0%, and 6.0% ± 0.7%, respectively (P < .001). Moderate had a greater peak force of the anterior primary chordae (0.43 ± 0.06 N) than those of baseline (0.19 ± 0.04 N; P = .011), mild (0.23 ± 0.05 N; P = .041), and perfect repair (0.21 ± 0.03 N; P = .006). In addition, moderate had a greater peak force of the anterior secondary chordae (1.67 ± 0.17 N) than those of baseline (0.64 ± 0.13 N; P = .003), mild (0.84 ± 0.24 N; P = .019), and perfect repair (0.68 ± 0.14 N; P = .001). No significant differences in peak and average forces on both primary and secondary anterior chordae were observed between the baseline and perfect repair as well as the mild and perfect repair. CONCLUSIONS: Moderate residual mitral regurgitation after neochord repair was associated with increased anterior primary and secondary chordae forces in our ex vivo anterior valve prolapse model. This difference in chordal force profile may influence long-term repair durability, providing biomechanical evidence in support of obtaining minimal regurgitation when repairing mitral anterior valve prolapse.
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spelling pubmed-105568252023-10-07 Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study Yajima, Shin Zhu, Yuanjia Stark, Charles J. Wilkerson, Robert J. Park, Matthew H. Stefan, Elde Woo, Y. Joseph JTCVS Open Adult: Mitral Valve: Evolving Technology OBJECTIVE: This study aimed to biomechanically evaluate the force profiles on the anterior primary and secondary chordae after neochord repair for anterior valve prolapse with varied degrees of residual mitral regurgitation using an ex vivo heart simulator. METHODS: The experiment used 8 healthy porcine mitral valves. Chordal forces were measured using fiber Bragg grating sensors on primary and secondary chordae from A2 segments. The anterior valve prolapse model was generated by excising 2 primary chordae at the A2 segment. Neochord repair was performed with 2 pairs of neochords. Varying neochord lengths simulated postrepair residual mitral regurgitation with regurgitant fraction at >30% (moderate), 10% to 30% (mild), and <10% (perfect repair). RESULTS: Regurgitant fractions of baseline, moderate, mild, and perfect repair were 4.7% ± 0.8%, 35.8% ± 2.1%, 19.8% ± 2.0%, and 6.0% ± 0.7%, respectively (P < .001). Moderate had a greater peak force of the anterior primary chordae (0.43 ± 0.06 N) than those of baseline (0.19 ± 0.04 N; P = .011), mild (0.23 ± 0.05 N; P = .041), and perfect repair (0.21 ± 0.03 N; P = .006). In addition, moderate had a greater peak force of the anterior secondary chordae (1.67 ± 0.17 N) than those of baseline (0.64 ± 0.13 N; P = .003), mild (0.84 ± 0.24 N; P = .019), and perfect repair (0.68 ± 0.14 N; P = .001). No significant differences in peak and average forces on both primary and secondary anterior chordae were observed between the baseline and perfect repair as well as the mild and perfect repair. CONCLUSIONS: Moderate residual mitral regurgitation after neochord repair was associated with increased anterior primary and secondary chordae forces in our ex vivo anterior valve prolapse model. This difference in chordal force profile may influence long-term repair durability, providing biomechanical evidence in support of obtaining minimal regurgitation when repairing mitral anterior valve prolapse. Elsevier 2023-05-06 /pmc/articles/PMC10556825/ /pubmed/37808060 http://dx.doi.org/10.1016/j.xjon.2023.04.011 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Adult: Mitral Valve: Evolving Technology
Yajima, Shin
Zhu, Yuanjia
Stark, Charles J.
Wilkerson, Robert J.
Park, Matthew H.
Stefan, Elde
Woo, Y. Joseph
Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title_full Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title_fullStr Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title_full_unstemmed Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title_short Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study
title_sort chordal force profile after neochordal repair of anterior mitral valve prolapse: an ex vivo study
topic Adult: Mitral Valve: Evolving Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556825/
https://www.ncbi.nlm.nih.gov/pubmed/37808060
http://dx.doi.org/10.1016/j.xjon.2023.04.011
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