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Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor

Background: Aberrant activation of RAS-RAF-MEK-ERK signaling pathway has been implicated in more than one-third of all malignancies. MEK inhibitors are promising therapeutic approaches to target this signaling pathway. Though four MEK inhibitors have been approved by FDA, these compounds possess eit...

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Detalles Bibliográficos
Autores principales:	Liu, Yahong, Cheng, Ying, Huang, Gongchao, Xia, Xiangying, Wang, Xingkai, Tian, Hongqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557067/ https://www.ncbi.nlm.nih.gov/pubmed/37808191 http://dx.doi.org/10.3389/fphar.2023.1271268

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