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Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles

Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high...

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Autores principales: Zhang, Ruru, Lu, Kuan, Xiao, Li, Hu, Xuelan, Cai, Wu, Liu, Linjiang, Liu, Yan, Li, Weihua, Zhou, Hui, Qian, Zhiyuan, Wang, Sixia, Chen, Can, Zeng, Jianfeng, Gao, Mingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557075/
https://www.ncbi.nlm.nih.gov/pubmed/37811376
http://dx.doi.org/10.3389/fbioe.2023.1279446
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author Zhang, Ruru
Lu, Kuan
Xiao, Li
Hu, Xuelan
Cai, Wu
Liu, Linjiang
Liu, Yan
Li, Weihua
Zhou, Hui
Qian, Zhiyuan
Wang, Sixia
Chen, Can
Zeng, Jianfeng
Gao, Mingyuan
author_facet Zhang, Ruru
Lu, Kuan
Xiao, Li
Hu, Xuelan
Cai, Wu
Liu, Linjiang
Liu, Yan
Li, Weihua
Zhou, Hui
Qian, Zhiyuan
Wang, Sixia
Chen, Can
Zeng, Jianfeng
Gao, Mingyuan
author_sort Zhang, Ruru
collection PubMed
description Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high spatial resolution, and lack of ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation and passive targeting toward plaque sites, rendering them conducive for MRI. In this study, we synthesized ultrasmall iron oxide nanoparticles of approximately 3 nm via high-temperature thermal decomposition. Subsequent surface modification facilitated the creation of a dual-modality magnetic resonance/fluorescence probe. Upon intravenous administration of the probes, MRI assessment of atherosclerotic plaques and diagnostic evaluation were conducted. The application of Flash-3D sequence imaging revealed vascular constriction at lesion sites, accompanied by a gradual signal amplification postprobe injection. T1-weighted imaging of the carotid artery unveiled a progressive signal ratio increase between plaques and controls within 72 h post-administration. Fluorescence imaging of isolated carotid arteries exhibited incremental lesion-to-control signal ratios. Additionally, T1 imaging of the aorta demonstrated an evolving signal enhancement over 48 h. Therefore, the ultrasmall iron oxide nanoparticles hold immense promise for early and noninvasive diagnosis of plaques, providing an avenue for dynamic evaluation over an extended time frame.
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spelling pubmed-105570752023-10-07 Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles Zhang, Ruru Lu, Kuan Xiao, Li Hu, Xuelan Cai, Wu Liu, Linjiang Liu, Yan Li, Weihua Zhou, Hui Qian, Zhiyuan Wang, Sixia Chen, Can Zeng, Jianfeng Gao, Mingyuan Front Bioeng Biotechnol Bioengineering and Biotechnology Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high spatial resolution, and lack of ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation and passive targeting toward plaque sites, rendering them conducive for MRI. In this study, we synthesized ultrasmall iron oxide nanoparticles of approximately 3 nm via high-temperature thermal decomposition. Subsequent surface modification facilitated the creation of a dual-modality magnetic resonance/fluorescence probe. Upon intravenous administration of the probes, MRI assessment of atherosclerotic plaques and diagnostic evaluation were conducted. The application of Flash-3D sequence imaging revealed vascular constriction at lesion sites, accompanied by a gradual signal amplification postprobe injection. T1-weighted imaging of the carotid artery unveiled a progressive signal ratio increase between plaques and controls within 72 h post-administration. Fluorescence imaging of isolated carotid arteries exhibited incremental lesion-to-control signal ratios. Additionally, T1 imaging of the aorta demonstrated an evolving signal enhancement over 48 h. Therefore, the ultrasmall iron oxide nanoparticles hold immense promise for early and noninvasive diagnosis of plaques, providing an avenue for dynamic evaluation over an extended time frame. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10557075/ /pubmed/37811376 http://dx.doi.org/10.3389/fbioe.2023.1279446 Text en Copyright © 2023 Zhang, Lu, Xiao, Hu, Cai, Liu, Liu, Li, Zhou, Qian, Wang, Chen, Zeng and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhang, Ruru
Lu, Kuan
Xiao, Li
Hu, Xuelan
Cai, Wu
Liu, Linjiang
Liu, Yan
Li, Weihua
Zhou, Hui
Qian, Zhiyuan
Wang, Sixia
Chen, Can
Zeng, Jianfeng
Gao, Mingyuan
Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title_full Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title_fullStr Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title_full_unstemmed Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title_short Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles
title_sort exploring atherosclerosis imaging with contrast-enhanced mri using pegylated ultrasmall iron oxide nanoparticles
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557075/
https://www.ncbi.nlm.nih.gov/pubmed/37811376
http://dx.doi.org/10.3389/fbioe.2023.1279446
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