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Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammato...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557227/ https://www.ncbi.nlm.nih.gov/pubmed/37798799 http://dx.doi.org/10.1186/s12985-023-02194-w |
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author | Yang, Xue Liu, Xue Nie, Yujun Zhan, Fei Zhu, Bin |
author_facet | Yang, Xue Liu, Xue Nie, Yujun Zhan, Fei Zhu, Bin |
author_sort | Yang, Xue |
collection | PubMed |
description | Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammatory cytokines, and necrosis of infected cells. Oxidative stress, which is mainly characterized as an imbalance in the production of reactive oxygen species (ROS) and antioxidant responses, interacts with all the pathophysiologic processes above and is receiving increasing attention in RSV infection. A gradual accumulation of evidence indicates that ROS overproduction plays an important role in the pathogenesis of severe RSV infection and serves as a major factor in pulmonary inflammation and tissue damage. Thus, antioxidants seem to be an effective treatment for severe RSV infection. This article mainly reviews the information on oxidative stress and ROS-mediated cellular events during RSV infection for the first time. |
format | Online Article Text |
id | pubmed-10557227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105572272023-10-07 Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants Yang, Xue Liu, Xue Nie, Yujun Zhan, Fei Zhu, Bin Virol J Review Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammatory cytokines, and necrosis of infected cells. Oxidative stress, which is mainly characterized as an imbalance in the production of reactive oxygen species (ROS) and antioxidant responses, interacts with all the pathophysiologic processes above and is receiving increasing attention in RSV infection. A gradual accumulation of evidence indicates that ROS overproduction plays an important role in the pathogenesis of severe RSV infection and serves as a major factor in pulmonary inflammation and tissue damage. Thus, antioxidants seem to be an effective treatment for severe RSV infection. This article mainly reviews the information on oxidative stress and ROS-mediated cellular events during RSV infection for the first time. BioMed Central 2023-10-05 /pmc/articles/PMC10557227/ /pubmed/37798799 http://dx.doi.org/10.1186/s12985-023-02194-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Yang, Xue Liu, Xue Nie, Yujun Zhan, Fei Zhu, Bin Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title | Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title_full | Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title_fullStr | Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title_full_unstemmed | Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title_short | Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants |
title_sort | oxidative stress and ros-mediated cellular events in rsv infection: potential protective roles of antioxidants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557227/ https://www.ncbi.nlm.nih.gov/pubmed/37798799 http://dx.doi.org/10.1186/s12985-023-02194-w |
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