Cargando…

Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammato...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xue, Liu, Xue, Nie, Yujun, Zhan, Fei, Zhu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557227/
https://www.ncbi.nlm.nih.gov/pubmed/37798799
http://dx.doi.org/10.1186/s12985-023-02194-w
_version_ 1785117042656935936
author Yang, Xue
Liu, Xue
Nie, Yujun
Zhan, Fei
Zhu, Bin
author_facet Yang, Xue
Liu, Xue
Nie, Yujun
Zhan, Fei
Zhu, Bin
author_sort Yang, Xue
collection PubMed
description Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammatory cytokines, and necrosis of infected cells. Oxidative stress, which is mainly characterized as an imbalance in the production of reactive oxygen species (ROS) and antioxidant responses, interacts with all the pathophysiologic processes above and is receiving increasing attention in RSV infection. A gradual accumulation of evidence indicates that ROS overproduction plays an important role in the pathogenesis of severe RSV infection and serves as a major factor in pulmonary inflammation and tissue damage. Thus, antioxidants seem to be an effective treatment for severe RSV infection. This article mainly reviews the information on oxidative stress and ROS-mediated cellular events during RSV infection for the first time.
format Online
Article
Text
id pubmed-10557227
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-105572272023-10-07 Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants Yang, Xue Liu, Xue Nie, Yujun Zhan, Fei Zhu, Bin Virol J Review Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammatory cytokines, and necrosis of infected cells. Oxidative stress, which is mainly characterized as an imbalance in the production of reactive oxygen species (ROS) and antioxidant responses, interacts with all the pathophysiologic processes above and is receiving increasing attention in RSV infection. A gradual accumulation of evidence indicates that ROS overproduction plays an important role in the pathogenesis of severe RSV infection and serves as a major factor in pulmonary inflammation and tissue damage. Thus, antioxidants seem to be an effective treatment for severe RSV infection. This article mainly reviews the information on oxidative stress and ROS-mediated cellular events during RSV infection for the first time. BioMed Central 2023-10-05 /pmc/articles/PMC10557227/ /pubmed/37798799 http://dx.doi.org/10.1186/s12985-023-02194-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Xue
Liu, Xue
Nie, Yujun
Zhan, Fei
Zhu, Bin
Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title_full Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title_fullStr Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title_full_unstemmed Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title_short Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants
title_sort oxidative stress and ros-mediated cellular events in rsv infection: potential protective roles of antioxidants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557227/
https://www.ncbi.nlm.nih.gov/pubmed/37798799
http://dx.doi.org/10.1186/s12985-023-02194-w
work_keys_str_mv AT yangxue oxidativestressandrosmediatedcellulareventsinrsvinfectionpotentialprotectiverolesofantioxidants
AT liuxue oxidativestressandrosmediatedcellulareventsinrsvinfectionpotentialprotectiverolesofantioxidants
AT nieyujun oxidativestressandrosmediatedcellulareventsinrsvinfectionpotentialprotectiverolesofantioxidants
AT zhanfei oxidativestressandrosmediatedcellulareventsinrsvinfectionpotentialprotectiverolesofantioxidants
AT zhubin oxidativestressandrosmediatedcellulareventsinrsvinfectionpotentialprotectiverolesofantioxidants