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Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients

This study was conducted to investigate the relationship between atrial fibrillation and the clinical prognosis of patients with sepsis in intensive care unit. A total of 21,538 sepsis patients were enrolled in the study based on the Medical Information Mart for Intensive Care IV database, of whom 6...

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Autores principales: Wang, Weiping, Dong, Yujiang, Zhang, Qian, Gao, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557240/
https://www.ncbi.nlm.nih.gov/pubmed/37803320
http://dx.doi.org/10.1186/s12871-023-02281-z
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author Wang, Weiping
Dong, Yujiang
Zhang, Qian
Gao, Hongmei
author_facet Wang, Weiping
Dong, Yujiang
Zhang, Qian
Gao, Hongmei
author_sort Wang, Weiping
collection PubMed
description This study was conducted to investigate the relationship between atrial fibrillation and the clinical prognosis of patients with sepsis in intensive care unit. A total of 21,538 sepsis patients were enrolled in the study based on the Medical Information Mart for Intensive Care IV database, of whom 6,759 had AF. Propensity score matching was used to compare the clinical characteristics and outcomes of patients with and without AF. Besides, the inverse probability of treatment weighting, univariate and multivariate Cox regression analyzes were performed. Of the 21,538 patients, 31.4% had AF. The prevalence of AF increased in a step-by-step manner with growing age. Patients with AF were older than those without AF. After PSM, 11,180 patients remained, comprising 5,790 matched pairs in both groups. In IPTW, AF was not associated with 28-day mortality [hazard ratio (HR), 1.07; 95% confidence interval (CI), 0.99–1.15]. In Kaplan-Meier analysis, it was not observed difference of 28-day mortality between patients with and without AF. AF could be associated with increased ICU LOS, hospital LOS and need for mechanical ventilation; however, it does not remain an independent short-term predictor of 28-day mortality among patients with sepsis after PSM with IPTW and multivariate analysis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-023-02281-z.
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spelling pubmed-105572402023-10-07 Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients Wang, Weiping Dong, Yujiang Zhang, Qian Gao, Hongmei BMC Anesthesiol Research This study was conducted to investigate the relationship between atrial fibrillation and the clinical prognosis of patients with sepsis in intensive care unit. A total of 21,538 sepsis patients were enrolled in the study based on the Medical Information Mart for Intensive Care IV database, of whom 6,759 had AF. Propensity score matching was used to compare the clinical characteristics and outcomes of patients with and without AF. Besides, the inverse probability of treatment weighting, univariate and multivariate Cox regression analyzes were performed. Of the 21,538 patients, 31.4% had AF. The prevalence of AF increased in a step-by-step manner with growing age. Patients with AF were older than those without AF. After PSM, 11,180 patients remained, comprising 5,790 matched pairs in both groups. In IPTW, AF was not associated with 28-day mortality [hazard ratio (HR), 1.07; 95% confidence interval (CI), 0.99–1.15]. In Kaplan-Meier analysis, it was not observed difference of 28-day mortality between patients with and without AF. AF could be associated with increased ICU LOS, hospital LOS and need for mechanical ventilation; however, it does not remain an independent short-term predictor of 28-day mortality among patients with sepsis after PSM with IPTW and multivariate analysis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-023-02281-z. BioMed Central 2023-10-06 /pmc/articles/PMC10557240/ /pubmed/37803320 http://dx.doi.org/10.1186/s12871-023-02281-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Weiping
Dong, Yujiang
Zhang, Qian
Gao, Hongmei
Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title_full Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title_fullStr Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title_full_unstemmed Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title_short Atrial fibrillation is not an independent determinant of 28-day mortality among critically III sepsis patients
title_sort atrial fibrillation is not an independent determinant of 28-day mortality among critically iii sepsis patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557240/
https://www.ncbi.nlm.nih.gov/pubmed/37803320
http://dx.doi.org/10.1186/s12871-023-02281-z
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