A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism

BACKGROUND: MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the respective universal methyl d...

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Detalles Bibliográficos
Autores principales: Matmat, Karim, Conart, Jean-Baptiste, Graindorge, Paul-Henri, El Kouche, Sandra, Hassan, Ziad, Siblini, Youssef, Umoret, Rémy, Safar, Ramia, Baspinar, Okan, Robert, Aurélie, Alberto, Jean-Marc, Oussalah, Abderrahim, Coelho, David, Guéant, Jean-Louis, Guéant-Rodriguez, Rosa-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557304/
https://www.ncbi.nlm.nih.gov/pubmed/37798757
http://dx.doi.org/10.1186/s13148-023-01567-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557304/
https://www.ncbi.nlm.nih.gov/pubmed/37798757
http://dx.doi.org/10.1186/s13148-023-01567-w

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