Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

BACKGROUND: Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to elucidate how IGH is developed. However, as CRISPR/Cas9 could induce chromothri...

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Detalles Bibliográficos
Autores principales: Guo, Tao, Chen, Guo-Qiao, Li, Xu-Fan, Wang, Meng, Liu, Kun-Ming, Yang, Xiao-Ying, Liu, Si-Cheng, Feng, Yi-Li, Liu, Peng-Yuan, Lin, Hui, Xie, An-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557318/
https://www.ncbi.nlm.nih.gov/pubmed/37803452
http://dx.doi.org/10.1186/s13073-023-01230-2

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