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Micro RNA210 expression in pregnancies with preeclampsia
Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological conditi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557445/ https://www.ncbi.nlm.nih.gov/pubmed/37808367 http://dx.doi.org/10.6026/97320630019319 |
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author | Paremmal, Shali Sharma, Nidhi Devi, Rama Gopi, Keerti |
author_facet | Paremmal, Shali Sharma, Nidhi Devi, Rama Gopi, Keerti |
author_sort | Paremmal, Shali |
collection | PubMed |
description | Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia. |
format | Online Article Text |
id | pubmed-10557445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-105574452023-10-07 Micro RNA210 expression in pregnancies with preeclampsia Paremmal, Shali Sharma, Nidhi Devi, Rama Gopi, Keerti Bioinformation Research Article Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia. Biomedical Informatics 2023-03-31 /pmc/articles/PMC10557445/ /pubmed/37808367 http://dx.doi.org/10.6026/97320630019319 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Paremmal, Shali Sharma, Nidhi Devi, Rama Gopi, Keerti Micro RNA210 expression in pregnancies with preeclampsia |
title | Micro RNA210 expression in pregnancies with preeclampsia |
title_full | Micro RNA210 expression in pregnancies with preeclampsia |
title_fullStr | Micro RNA210 expression in pregnancies with preeclampsia |
title_full_unstemmed | Micro RNA210 expression in pregnancies with preeclampsia |
title_short | Micro RNA210 expression in pregnancies with preeclampsia |
title_sort | micro rna210 expression in pregnancies with preeclampsia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557445/ https://www.ncbi.nlm.nih.gov/pubmed/37808367 http://dx.doi.org/10.6026/97320630019319 |
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