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Micro RNA210 expression in pregnancies with preeclampsia

Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological conditi...

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Autores principales: Paremmal, Shali, Sharma, Nidhi, Devi, Rama, Gopi, Keerti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557445/
https://www.ncbi.nlm.nih.gov/pubmed/37808367
http://dx.doi.org/10.6026/97320630019319
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author Paremmal, Shali
Sharma, Nidhi
Devi, Rama
Gopi, Keerti
author_facet Paremmal, Shali
Sharma, Nidhi
Devi, Rama
Gopi, Keerti
author_sort Paremmal, Shali
collection PubMed
description Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia.
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spelling pubmed-105574452023-10-07 Micro RNA210 expression in pregnancies with preeclampsia Paremmal, Shali Sharma, Nidhi Devi, Rama Gopi, Keerti Bioinformation Research Article Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia. Biomedical Informatics 2023-03-31 /pmc/articles/PMC10557445/ /pubmed/37808367 http://dx.doi.org/10.6026/97320630019319 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Paremmal, Shali
Sharma, Nidhi
Devi, Rama
Gopi, Keerti
Micro RNA210 expression in pregnancies with preeclampsia
title Micro RNA210 expression in pregnancies with preeclampsia
title_full Micro RNA210 expression in pregnancies with preeclampsia
title_fullStr Micro RNA210 expression in pregnancies with preeclampsia
title_full_unstemmed Micro RNA210 expression in pregnancies with preeclampsia
title_short Micro RNA210 expression in pregnancies with preeclampsia
title_sort micro rna210 expression in pregnancies with preeclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557445/
https://www.ncbi.nlm.nih.gov/pubmed/37808367
http://dx.doi.org/10.6026/97320630019319
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