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Phytochemical cocktail of Asanadi ganaextract in the management of diabetes
It is of interest to investigate that the phytochemical analysis, in-vitro antioxidant potential and glycosidase inhibitory potential of Asanadi ganaa polyherbal formulation. Asanadi ganais a classical Ayurvedic polyherbal formulation, markedly used for alleviation of Prameha and Medodosha, which co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557453/ https://www.ncbi.nlm.nih.gov/pubmed/37808369 http://dx.doi.org/10.6026/97320630019299 |
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author | Dulala, Rekha Kumari Balraj, Manikandan Chandrashekar, Sangeeta N, Muninathan Rajapandiyan, Nithiya Badrachalam, Ramya Mani, Vadivel |
author_facet | Dulala, Rekha Kumari Balraj, Manikandan Chandrashekar, Sangeeta N, Muninathan Rajapandiyan, Nithiya Badrachalam, Ramya Mani, Vadivel |
author_sort | Dulala, Rekha Kumari |
collection | PubMed |
description | It is of interest to investigate that the phytochemical analysis, in-vitro antioxidant potential and glycosidase inhibitory potential of Asanadi ganaa polyherbal formulation. Asanadi ganais a classical Ayurvedic polyherbal formulation, markedly used for alleviation of Prameha and Medodosha, which correlates in many ways with obesity, metabolic syndrome, and diabetes mellitus (madhumeha). The phytochemical constituents, total phenolic, total flavonoids, total tannin content, total antioxidant capacity, total reducing power, and free radical scavenging activity of the polyherbal formulation extracts were determined. Comparing it to the common medication Acarbose, its inhibitory impact against the digestive enzymes α-amylase and α-glucosidase was also examined. The formulation showed the presence of major constituents such as terpenoids, triterpenoids, sterols, flavonoids, tannins, phenolic, saponins, alkaloids and Glycosides. The ethanol extract had high phenolic content and flavonoid content, whereas the aqueous extract had more tannin content (181 ± 5.5µg/mg), (132 ± 5.50 µg/mg), (22± 1.6 µg/mg respectively. we conclude that the extracts of ayurvedic polyherbal formulations, particularly ethanol extract are a potential source of natural antioxidants and remarkable glycosidase inhibitory activity. Hence, Asanadi ganahas the potential to be a safe and effective natural treatment for the delay or prevention of diabetic complications. |
format | Online Article Text |
id | pubmed-10557453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-105574532023-10-07 Phytochemical cocktail of Asanadi ganaextract in the management of diabetes Dulala, Rekha Kumari Balraj, Manikandan Chandrashekar, Sangeeta N, Muninathan Rajapandiyan, Nithiya Badrachalam, Ramya Mani, Vadivel Bioinformation Research Article It is of interest to investigate that the phytochemical analysis, in-vitro antioxidant potential and glycosidase inhibitory potential of Asanadi ganaa polyherbal formulation. Asanadi ganais a classical Ayurvedic polyherbal formulation, markedly used for alleviation of Prameha and Medodosha, which correlates in many ways with obesity, metabolic syndrome, and diabetes mellitus (madhumeha). The phytochemical constituents, total phenolic, total flavonoids, total tannin content, total antioxidant capacity, total reducing power, and free radical scavenging activity of the polyherbal formulation extracts were determined. Comparing it to the common medication Acarbose, its inhibitory impact against the digestive enzymes α-amylase and α-glucosidase was also examined. The formulation showed the presence of major constituents such as terpenoids, triterpenoids, sterols, flavonoids, tannins, phenolic, saponins, alkaloids and Glycosides. The ethanol extract had high phenolic content and flavonoid content, whereas the aqueous extract had more tannin content (181 ± 5.5µg/mg), (132 ± 5.50 µg/mg), (22± 1.6 µg/mg respectively. we conclude that the extracts of ayurvedic polyherbal formulations, particularly ethanol extract are a potential source of natural antioxidants and remarkable glycosidase inhibitory activity. Hence, Asanadi ganahas the potential to be a safe and effective natural treatment for the delay or prevention of diabetic complications. Biomedical Informatics 2023-03-31 /pmc/articles/PMC10557453/ /pubmed/37808369 http://dx.doi.org/10.6026/97320630019299 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Dulala, Rekha Kumari Balraj, Manikandan Chandrashekar, Sangeeta N, Muninathan Rajapandiyan, Nithiya Badrachalam, Ramya Mani, Vadivel Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title | Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title_full | Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title_fullStr | Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title_full_unstemmed | Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title_short | Phytochemical cocktail of Asanadi ganaextract in the management of diabetes |
title_sort | phytochemical cocktail of asanadi ganaextract in the management of diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557453/ https://www.ncbi.nlm.nih.gov/pubmed/37808369 http://dx.doi.org/10.6026/97320630019299 |
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