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High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46

OBJECTIVE: The aim of the study was to investigate are there associations between common female sex-specific health conditions (oligo/amenorrhea, hyperandrogenism, menopause and polycystic ovary syndrome [PCOS]) and high-sensitivity troponin-T (hs-TnT) levels. METHODS: Cross-sectional and longitudin...

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Autores principales: Ollila, Meri-Maija, Arffman, Riikka K., Kaikkonen, Kari, Morin-Papunen, Laure, Junttila, Juhani, Piltonen, Terhi T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557532/
https://www.ncbi.nlm.nih.gov/pubmed/37795692
http://dx.doi.org/10.1080/07853890.2023.2264340
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author Ollila, Meri-Maija
Arffman, Riikka K.
Kaikkonen, Kari
Morin-Papunen, Laure
Junttila, Juhani
Piltonen, Terhi T.
author_facet Ollila, Meri-Maija
Arffman, Riikka K.
Kaikkonen, Kari
Morin-Papunen, Laure
Junttila, Juhani
Piltonen, Terhi T.
author_sort Ollila, Meri-Maija
collection PubMed
description OBJECTIVE: The aim of the study was to investigate are there associations between common female sex-specific health conditions (oligo/amenorrhea, hyperandrogenism, menopause and polycystic ovary syndrome [PCOS]) and high-sensitivity troponin-T (hs-TnT) levels. METHODS: Cross-sectional and longitudinal analyses of a general population-based prospective cohort study were performed. The hs-TnT levels of 3146 women aged 46 were measured using an Elecsys® Troponin T high-sensitivity assay. Median hs-TnT levels and 25 and 75 percentiles of the cases and controls were compared. Also, a logistic regression analysis using a binary outcome – undetectable hs-TnT (< 3.0 ng/L) versus detectable hs-TnT (≥ 3.0 ng/L) – was performed. RESULTS: Women with oligo/amenorrhea at age 31 had significantly higher hs-TnT levels at age 46 than women without oligo/amenorrhea (4.06 [3.59; 4.86] vs 3.98 [3.44; 4.71] ng/L, p = .042). Menopausal women had significantly higher hs-TnT levels than premenopausal women (4.15 [3.54; 4.91] vs 3.95 [3.45; 4.68] ng/L, p = .012) at age 46. Women with PCOS or hyperandrogenism had comparable hs-TnT levels with their controls. In the adjusted logistic regression analysis, oligo/amenorrhea (odds ratio [OR] = 1.52 [0.90–2.57]), hyperandrogenism (OR = 1.20 [0.75–1.92]), PCOS (OR = 1.51 [0.81–2.84]) and menopause (OR = 1.05 [0.63–1.74]) were not significantly associated with detectable hs-TnT. CONCLUSIONS: This study was the first to investigate how oligo/amenorrhea, hyperandrogenism, PCOS and menopause are associated with hs-TnT. Although women with oligo/amenorrhea and menopause had higher hs-TnT levels than women without these conditions, the difference was small. Larger studies are required to better understand the effects of oligo/amenorrhea on cardiovascular health.
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spelling pubmed-105575322023-10-07 High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46 Ollila, Meri-Maija Arffman, Riikka K. Kaikkonen, Kari Morin-Papunen, Laure Junttila, Juhani Piltonen, Terhi T. Ann Med Cardiology & Cardiovascular Disorders OBJECTIVE: The aim of the study was to investigate are there associations between common female sex-specific health conditions (oligo/amenorrhea, hyperandrogenism, menopause and polycystic ovary syndrome [PCOS]) and high-sensitivity troponin-T (hs-TnT) levels. METHODS: Cross-sectional and longitudinal analyses of a general population-based prospective cohort study were performed. The hs-TnT levels of 3146 women aged 46 were measured using an Elecsys® Troponin T high-sensitivity assay. Median hs-TnT levels and 25 and 75 percentiles of the cases and controls were compared. Also, a logistic regression analysis using a binary outcome – undetectable hs-TnT (< 3.0 ng/L) versus detectable hs-TnT (≥ 3.0 ng/L) – was performed. RESULTS: Women with oligo/amenorrhea at age 31 had significantly higher hs-TnT levels at age 46 than women without oligo/amenorrhea (4.06 [3.59; 4.86] vs 3.98 [3.44; 4.71] ng/L, p = .042). Menopausal women had significantly higher hs-TnT levels than premenopausal women (4.15 [3.54; 4.91] vs 3.95 [3.45; 4.68] ng/L, p = .012) at age 46. Women with PCOS or hyperandrogenism had comparable hs-TnT levels with their controls. In the adjusted logistic regression analysis, oligo/amenorrhea (odds ratio [OR] = 1.52 [0.90–2.57]), hyperandrogenism (OR = 1.20 [0.75–1.92]), PCOS (OR = 1.51 [0.81–2.84]) and menopause (OR = 1.05 [0.63–1.74]) were not significantly associated with detectable hs-TnT. CONCLUSIONS: This study was the first to investigate how oligo/amenorrhea, hyperandrogenism, PCOS and menopause are associated with hs-TnT. Although women with oligo/amenorrhea and menopause had higher hs-TnT levels than women without these conditions, the difference was small. Larger studies are required to better understand the effects of oligo/amenorrhea on cardiovascular health. Taylor & Francis 2023-10-05 /pmc/articles/PMC10557532/ /pubmed/37795692 http://dx.doi.org/10.1080/07853890.2023.2264340 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Cardiology & Cardiovascular Disorders
Ollila, Meri-Maija
Arffman, Riikka K.
Kaikkonen, Kari
Morin-Papunen, Laure
Junttila, Juhani
Piltonen, Terhi T.
High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title_full High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title_fullStr High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title_full_unstemmed High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title_short High-sensitivity troponin-T levels and associated health conditions in 3146 women aged 46
title_sort high-sensitivity troponin-t levels and associated health conditions in 3146 women aged 46
topic Cardiology & Cardiovascular Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557532/
https://www.ncbi.nlm.nih.gov/pubmed/37795692
http://dx.doi.org/10.1080/07853890.2023.2264340
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