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Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patien...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557553/ https://www.ncbi.nlm.nih.gov/pubmed/37795782 http://dx.doi.org/10.1080/0886022X.2023.2265665 |
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author | Lee, Yoo Jin Park, Kang Min Heo, Chang Min Park, Sihyung Kim, Yang Wook Lee, Dongyeol Kim, Yunmi Oh, Joon Seok Shin, Ho Sik Park, Bong Soo |
author_facet | Lee, Yoo Jin Park, Kang Min Heo, Chang Min Park, Sihyung Kim, Yang Wook Lee, Dongyeol Kim, Yunmi Oh, Joon Seok Shin, Ho Sik Park, Bong Soo |
author_sort | Lee, Yoo Jin |
collection | PubMed |
description | INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patients with ESKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. MATERIALS AND METHODS: This study was prospectively conducted at a single hospital. We enrolled 14 neurologically asymptomatic patients who first initiated hemodialysis or peritoneal dialysis for ESKD and 17 healthy controls. Patients had magnetic resonance imaging scans before initiating dialysis and again 3 months after initiating dialysis and the DTI-ALPS index was calculated. We compared the DTI-ALPS index before and after the initiation of dialysis and compared the DTI-ALPS index between the patients with ESKD and healthy control. RESULTS: There were differences in the DTI-ALPS index between ESKD patients before initiating dialysis and healthy controls (1.342 vs. 1.633, p = 0.003). DTI-ALPS index between ESKD patients before initiating dialysis and those after dialysis were not different (1.342 vs. 1.262, p = 0.386). There was a positive correlation between DTI-ALPS index and phosphate (r = 0.610, p = 0.020) in patients with ESKD. CONCLUSION: We confirmed the presence of glymphatic dysfunction in patients with ESKD. However, there was no difference in the glymphatic system before and after dialysis initiation. This finding may be related to uremic toxins that are not removed by dialysis in patients with ESKD. This study can be used for the development of pathophysiology of patients with ESKD. |
format | Online Article Text |
id | pubmed-10557553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-105575532023-10-07 Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease Lee, Yoo Jin Park, Kang Min Heo, Chang Min Park, Sihyung Kim, Yang Wook Lee, Dongyeol Kim, Yunmi Oh, Joon Seok Shin, Ho Sik Park, Bong Soo Ren Fail Clinical Study INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patients with ESKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. MATERIALS AND METHODS: This study was prospectively conducted at a single hospital. We enrolled 14 neurologically asymptomatic patients who first initiated hemodialysis or peritoneal dialysis for ESKD and 17 healthy controls. Patients had magnetic resonance imaging scans before initiating dialysis and again 3 months after initiating dialysis and the DTI-ALPS index was calculated. We compared the DTI-ALPS index before and after the initiation of dialysis and compared the DTI-ALPS index between the patients with ESKD and healthy control. RESULTS: There were differences in the DTI-ALPS index between ESKD patients before initiating dialysis and healthy controls (1.342 vs. 1.633, p = 0.003). DTI-ALPS index between ESKD patients before initiating dialysis and those after dialysis were not different (1.342 vs. 1.262, p = 0.386). There was a positive correlation between DTI-ALPS index and phosphate (r = 0.610, p = 0.020) in patients with ESKD. CONCLUSION: We confirmed the presence of glymphatic dysfunction in patients with ESKD. However, there was no difference in the glymphatic system before and after dialysis initiation. This finding may be related to uremic toxins that are not removed by dialysis in patients with ESKD. This study can be used for the development of pathophysiology of patients with ESKD. Taylor & Francis 2023-10-05 /pmc/articles/PMC10557553/ /pubmed/37795782 http://dx.doi.org/10.1080/0886022X.2023.2265665 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Clinical Study Lee, Yoo Jin Park, Kang Min Heo, Chang Min Park, Sihyung Kim, Yang Wook Lee, Dongyeol Kim, Yunmi Oh, Joon Seok Shin, Ho Sik Park, Bong Soo Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title | Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title_full | Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title_fullStr | Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title_full_unstemmed | Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title_short | Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
title_sort | changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557553/ https://www.ncbi.nlm.nih.gov/pubmed/37795782 http://dx.doi.org/10.1080/0886022X.2023.2265665 |
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