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Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease

INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patien...

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Autores principales: Lee, Yoo Jin, Park, Kang Min, Heo, Chang Min, Park, Sihyung, Kim, Yang Wook, Lee, Dongyeol, Kim, Yunmi, Oh, Joon Seok, Shin, Ho Sik, Park, Bong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557553/
https://www.ncbi.nlm.nih.gov/pubmed/37795782
http://dx.doi.org/10.1080/0886022X.2023.2265665
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author Lee, Yoo Jin
Park, Kang Min
Heo, Chang Min
Park, Sihyung
Kim, Yang Wook
Lee, Dongyeol
Kim, Yunmi
Oh, Joon Seok
Shin, Ho Sik
Park, Bong Soo
author_facet Lee, Yoo Jin
Park, Kang Min
Heo, Chang Min
Park, Sihyung
Kim, Yang Wook
Lee, Dongyeol
Kim, Yunmi
Oh, Joon Seok
Shin, Ho Sik
Park, Bong Soo
author_sort Lee, Yoo Jin
collection PubMed
description INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patients with ESKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. MATERIALS AND METHODS: This study was prospectively conducted at a single hospital. We enrolled 14 neurologically asymptomatic patients who first initiated hemodialysis or peritoneal dialysis for ESKD and 17 healthy controls. Patients had magnetic resonance imaging scans before initiating dialysis and again 3 months after initiating dialysis and the DTI-ALPS index was calculated. We compared the DTI-ALPS index before and after the initiation of dialysis and compared the DTI-ALPS index between the patients with ESKD and healthy control. RESULTS: There were differences in the DTI-ALPS index between ESKD patients before initiating dialysis and healthy controls (1.342 vs. 1.633, p = 0.003). DTI-ALPS index between ESKD patients before initiating dialysis and those after dialysis were not different (1.342 vs. 1.262, p = 0.386). There was a positive correlation between DTI-ALPS index and phosphate (r = 0.610, p = 0.020) in patients with ESKD. CONCLUSION: We confirmed the presence of glymphatic dysfunction in patients with ESKD. However, there was no difference in the glymphatic system before and after dialysis initiation. This finding may be related to uremic toxins that are not removed by dialysis in patients with ESKD. This study can be used for the development of pathophysiology of patients with ESKD.
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spelling pubmed-105575532023-10-07 Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease Lee, Yoo Jin Park, Kang Min Heo, Chang Min Park, Sihyung Kim, Yang Wook Lee, Dongyeol Kim, Yunmi Oh, Joon Seok Shin, Ho Sik Park, Bong Soo Ren Fail Clinical Study INTRODUCTION: The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney replacement therapy including dialysis in patients with ESKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. MATERIALS AND METHODS: This study was prospectively conducted at a single hospital. We enrolled 14 neurologically asymptomatic patients who first initiated hemodialysis or peritoneal dialysis for ESKD and 17 healthy controls. Patients had magnetic resonance imaging scans before initiating dialysis and again 3 months after initiating dialysis and the DTI-ALPS index was calculated. We compared the DTI-ALPS index before and after the initiation of dialysis and compared the DTI-ALPS index between the patients with ESKD and healthy control. RESULTS: There were differences in the DTI-ALPS index between ESKD patients before initiating dialysis and healthy controls (1.342 vs. 1.633, p = 0.003). DTI-ALPS index between ESKD patients before initiating dialysis and those after dialysis were not different (1.342 vs. 1.262, p = 0.386). There was a positive correlation between DTI-ALPS index and phosphate (r = 0.610, p = 0.020) in patients with ESKD. CONCLUSION: We confirmed the presence of glymphatic dysfunction in patients with ESKD. However, there was no difference in the glymphatic system before and after dialysis initiation. This finding may be related to uremic toxins that are not removed by dialysis in patients with ESKD. This study can be used for the development of pathophysiology of patients with ESKD. Taylor & Francis 2023-10-05 /pmc/articles/PMC10557553/ /pubmed/37795782 http://dx.doi.org/10.1080/0886022X.2023.2265665 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Clinical Study
Lee, Yoo Jin
Park, Kang Min
Heo, Chang Min
Park, Sihyung
Kim, Yang Wook
Lee, Dongyeol
Kim, Yunmi
Oh, Joon Seok
Shin, Ho Sik
Park, Bong Soo
Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title_full Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title_fullStr Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title_full_unstemmed Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title_short Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
title_sort changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557553/
https://www.ncbi.nlm.nih.gov/pubmed/37795782
http://dx.doi.org/10.1080/0886022X.2023.2265665
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