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iPSC-based modeling of helicase deficiency reveals impaired cell proliferation and increased apoptosis after NK cell lineage commitment

Cell proliferation is a ubiquitous process required for organismal development and homeostasis. However, individuals with partial loss-of-function variants in DNA replicative helicase components often present with immunodeficiency due to specific loss of natural killer (NK) cells. Such lineage-speci...

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Detalles Bibliográficos
Autores principales:	Seo, Seungmae, Patil, Sagar L., Ahn, Yong-Oon, Armetta, Jacqueline, Hegewisch-Solloa, Everardo, Castillo, Micah, Guilz, Nicole C., Patel, Achchhe, Corneo, Barbara, Borowiak, Malgorzata, Gunaratne, Preethi, Mace, Emily M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557596/ https://www.ncbi.nlm.nih.gov/pubmed/37808662 http://dx.doi.org/10.1101/2023.09.25.559149

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