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Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain

The enzymatic activity of the SARS-CoV-2 nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain is essential for viral propagation, with three distinct activities associated with modification of the nsp9 N-terminus, NMPylation, RNAylation, and deRNAylation/capping via a GDP-polyribonucleoti...

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Detalles Bibliográficos
Autores principales:	Small, Gabriel I., Fedorova, Olga, Olinares, Paul Dominic B., Chandanani, Joshua, Banerjee, Anoosha, Choi, Young Joo, Molina, Henrik, Chait, Brian, Darst, Seth A., Campbell, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557602/ https://www.ncbi.nlm.nih.gov/pubmed/37808858 http://dx.doi.org/10.1101/2023.09.25.558837

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