Context-aware single-cell multiome approach identified cell-type specific lung cancer susceptibility genes

Genome-wide association studies (GWAS) identified over fifty loci associated with lung cancer risk. However, the genetic mechanisms and target genes underlying these loci are largely unknown, as most risk-associated-variants might regulate gene expression in a context-specific manner. Here, we gener...

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Detalles Bibliográficos
Autores principales: Long, Erping, Yin, Jinhu, Shin, Ju Hye, Li, Yuyan, Kane, Alexander, Patel, Harsh, Luong, Thong, Xia, Jun, Han, Younghun, Byun, Jinyoung, Zhang, Tongwu, Zhao, Wei, Landi, Maria Teresa, Rothman, Nathaniel, Lan, Qing, Chang, Yoon Soo, Yu, Fulong, Amos, Christopher, Shi, Jianxin, Lee, Jin Gu, Kim, Eun Young, Choi, Jiyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557605/
https://www.ncbi.nlm.nih.gov/pubmed/37808664
http://dx.doi.org/10.1101/2023.09.25.559336

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