BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data

MOTIVATION: With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. RESULTS: BAllC (Binary All Cytosines) emerges as a tailored binary format for methyl...

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Detalles Bibliográficos
Autores principales: Tian, Wei, Ding, Wubin, Ecker, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557610/
https://www.ncbi.nlm.nih.gov/pubmed/37808734
http://dx.doi.org/10.1101/2023.09.22.559047
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author Tian, Wei
Ding, Wubin
Ecker, Joseph R.
author_facet Tian, Wei
Ding, Wubin
Ecker, Joseph R.
author_sort Tian, Wei
collection PubMed
description MOTIVATION: With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. RESULTS: BAllC (Binary All Cytosines) emerges as a tailored binary format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs. AVAILABILITY: https://github.com/jksr/ballcools
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spelling pubmed-105576102023-10-07 BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data Tian, Wei Ding, Wubin Ecker, Joseph R. bioRxiv Article MOTIVATION: With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. RESULTS: BAllC (Binary All Cytosines) emerges as a tailored binary format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs. AVAILABILITY: https://github.com/jksr/ballcools Cold Spring Harbor Laboratory 2023-09-25 /pmc/articles/PMC10557610/ /pubmed/37808734 http://dx.doi.org/10.1101/2023.09.22.559047 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Tian, Wei
Ding, Wubin
Ecker, Joseph R.
BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title_full BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title_fullStr BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title_full_unstemmed BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title_short BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data
title_sort ballc and ballcools: efficient formatting and operating for single-cell dna methylation data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557610/
https://www.ncbi.nlm.nih.gov/pubmed/37808734
http://dx.doi.org/10.1101/2023.09.22.559047
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