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The influence of microbiota on ferroptosis in intestinal diseases

Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant defenses. Multiple metabolic pathways, including iron and lipid metabolism, as well as antioxidant systems, contribute to...

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Detalles Bibliográficos
Autores principales: Yao, Ting, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557621/
https://www.ncbi.nlm.nih.gov/pubmed/37795964
http://dx.doi.org/10.1080/19490976.2023.2263210
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author Yao, Ting
Li, Lanjuan
author_facet Yao, Ting
Li, Lanjuan
author_sort Yao, Ting
collection PubMed
description Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant defenses. Multiple metabolic pathways, including iron and lipid metabolism, as well as antioxidant systems, contribute to the execution of ferroptosis. The gut microbiota exerts regulatory effects on ferroptosis through its microbial composition, biological functions, and metabolites. Notably, most pathogenic bacteria tend to promote ferroptosis, thereby inducing or exacerbating diseases, while most probiotics have been shown to protect against cell death. Given microbiota colonization in the gut, an intimate association is found between intestinal diseases and microbiota. This review consolidates the essential aspects of ferroptotic processes, emphasizing key molecules and delineating the intricate interplay between gut microbiota and ferroptosis. Moreover, this review underscores the potential utility of gut microbiota modulation in regulating ferroptosis for the treatment of intestinal diseases.
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spelling pubmed-105576212023-10-07 The influence of microbiota on ferroptosis in intestinal diseases Yao, Ting Li, Lanjuan Gut Microbes Review Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant defenses. Multiple metabolic pathways, including iron and lipid metabolism, as well as antioxidant systems, contribute to the execution of ferroptosis. The gut microbiota exerts regulatory effects on ferroptosis through its microbial composition, biological functions, and metabolites. Notably, most pathogenic bacteria tend to promote ferroptosis, thereby inducing or exacerbating diseases, while most probiotics have been shown to protect against cell death. Given microbiota colonization in the gut, an intimate association is found between intestinal diseases and microbiota. This review consolidates the essential aspects of ferroptotic processes, emphasizing key molecules and delineating the intricate interplay between gut microbiota and ferroptosis. Moreover, this review underscores the potential utility of gut microbiota modulation in regulating ferroptosis for the treatment of intestinal diseases. Taylor & Francis 2023-10-05 /pmc/articles/PMC10557621/ /pubmed/37795964 http://dx.doi.org/10.1080/19490976.2023.2263210 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review
Yao, Ting
Li, Lanjuan
The influence of microbiota on ferroptosis in intestinal diseases
title The influence of microbiota on ferroptosis in intestinal diseases
title_full The influence of microbiota on ferroptosis in intestinal diseases
title_fullStr The influence of microbiota on ferroptosis in intestinal diseases
title_full_unstemmed The influence of microbiota on ferroptosis in intestinal diseases
title_short The influence of microbiota on ferroptosis in intestinal diseases
title_sort influence of microbiota on ferroptosis in intestinal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557621/
https://www.ncbi.nlm.nih.gov/pubmed/37795964
http://dx.doi.org/10.1080/19490976.2023.2263210
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