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Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice

Gammaherpesviruses (GHVs) are oncogenic viruses that establish lifelong infections and are significant causes of human morbidity and mortality. While several vaccine strategies to limit GHV infection and disease are in development, there are no FDA-approved vaccines for human GHVs. As a new approach...

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Detalles Bibliográficos
Autores principales: Bland, Wesley A., Owens, Shana, McEvoy, Kyle, Hogan, Chad H., Boccuzzi, Luciarita, Kirillov, Varvara, Khairallah, Camille, Sheridan, Brian S., Forrest, J. Craig, Krug, Laurie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557649/
https://www.ncbi.nlm.nih.gov/pubmed/37808844
http://dx.doi.org/10.1101/2023.09.26.559621