Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-related macular degeneration (AMD). Here we identified interleukin-1 receptor-associated kinase (IRAK)-M as a key immunoregulator in retinal pigment epithelium (RPE) that declines with age. Rare geneti...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Copland, David A., Clare, Alison J., Gorski, Mathias, Richards, Burt T., Scott, Louis, Theodoropoulou, Sofia, Greferath, Ursula, Cox, Katherine, Bell, Oliver H., Ou, Kepeng, Powell, Jenna Le Brun, Wu, Jiahui, Robles, Luis Martinez, Li, Yingxin, Nicholson, Lindsay B., Coffey, Peter J., Fletcher, Erica L., Guymer, Robyn, Radeke, Monte J., Heid, Iris M., Hageman, Gregory S., Chan, Ying Kai, Dick, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557650/
https://www.ncbi.nlm.nih.gov/pubmed/37808640
http://dx.doi.org/10.1101/2023.09.27.559733

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