The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

The transporter associated with antigen processing (TAP) is a key player in the MHC class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 (BoHV-1) impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in which...

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Detalles Bibliográficos
Autores principales: Wąhalska, Magda, Riepe, Celeste, Ślusarz, Magdalena J., Graul, Małgorzata, Borowski, Lukasz S., Qiao, Wenjie, Foltynska, Michalina, Carette, Jan E., Bieńkowska-Szewczyk, Krystyna, Szczesny, Roman J., Kopito, Ron R., Lipińska, Andrea D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557673/
https://www.ncbi.nlm.nih.gov/pubmed/37808699
http://dx.doi.org/10.1101/2023.09.27.559663

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