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Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo

The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses the human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here, we design and characterize a mutant ACE2 that enables rapi...

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Detalles Bibliográficos
Autores principales:	Kober, Daniel L., Caballero Van Dyke, Marley C., Eitson, Jennifer L., Boys, Ian N., McDougal, Matthew B., Rosenbaum, Daniel M., Schoggins, John W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557691/ https://www.ncbi.nlm.nih.gov/pubmed/37808801 http://dx.doi.org/10.1101/2023.09.26.559550

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