5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cells

Enzymatic erasure of DNA methylation in mammals involves iterative 5-methylcytosine (5mC) oxidation by the ten-eleven translocation (TET) family of DNA dioxygenase proteins. As the most abundant form of oxidized 5mC, the prevailing model considers 5-hydroxymethylcytosine (5hmC) as a key nexus in act...

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Detalles Bibliográficos
Autores principales: Wei, Alex, Zhang, Hongjie, Qiu, Qi, Fabyanic, Emily B., Hu, Peng, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557716/
https://www.ncbi.nlm.nih.gov/pubmed/37808741
http://dx.doi.org/10.1101/2023.09.26.559662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557716/
https://www.ncbi.nlm.nih.gov/pubmed/37808741
http://dx.doi.org/10.1101/2023.09.26.559662

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