Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models

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CIC-DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and DUX4. Currently, there are no effective treatments and efforts to identify and translate better therapies are limited by the scarcity of...

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Detalles Bibliográficos
Autores principales: Hendrickson, Peter G., Oristian, Kristianne M., Browne, MaKenna R., Lou, Lixia, Ma, Yan, Cardona, Dianna M., Linardic, Corinne M., Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557731/
https://www.ncbi.nlm.nih.gov/pubmed/37808628
http://dx.doi.org/10.1101/2023.09.26.559519
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