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Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively(1–6). Despite the importance of these lipids, the mechanisms that enable the cellular uptake of choline...

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Detalles Bibliográficos
Autores principales: Son, Yeeun, Kenny, Timothy C., Khan, Artem, Birsoy, Kivanç, Hite, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557757/
https://www.ncbi.nlm.nih.gov/pubmed/37808796
http://dx.doi.org/10.1101/2023.09.28.560019