Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors

Altered metabolism is a hallmark of cancer; however, it has been difficult to specifically target metabolism in cancer for therapeutic benefit. Cancers with genetically defined defects in metabolic enzymes constitute a subset of cancers where targeting metabolism is potentially accessible. Hürthle c...

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Detalles Bibliográficos
Autores principales: Frank, Anderson R, Vandiver, Florentina, McFadden, David G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557759/
https://www.ncbi.nlm.nih.gov/pubmed/37808702
http://dx.doi.org/10.1101/2023.09.30.560315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557759/
https://www.ncbi.nlm.nih.gov/pubmed/37808702
http://dx.doi.org/10.1101/2023.09.30.560315

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