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Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors
Altered metabolism is a hallmark of cancer; however, it has been difficult to specifically target metabolism in cancer for therapeutic benefit. Cancers with genetically defined defects in metabolic enzymes constitute a subset of cancers where targeting metabolism is potentially accessible. Hürthle c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557759/ https://www.ncbi.nlm.nih.gov/pubmed/37808702 http://dx.doi.org/10.1101/2023.09.30.560315 |