Cargando…

Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging

The brain is a high energy tissue, and the cell types of which it is comprised are distinct in function and in metabolic requirements. The transcriptional co-activator PGC-1a is a master regulator of mitochondrial function and is highly expressed in the brain; however, its cell-type specific role in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Souder, Dylan C, McGregor, Eric R, Rhoads, Timothy W, Clark, Josef P, Porter, Tiaira J, Eliceiri, Kevin, Moore, Darcie L, Puglielli, Luigi, Anderson, Rozalyn M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557769/ https://www.ncbi.nlm.nih.gov/pubmed/37808866 http://dx.doi.org/10.1101/2023.09.29.559526

Ejemplares similares

GSK3β Regulates Brain Energy Metabolism
por: Martin, Stephen A., et al.
Publicado: (2018)

Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells
por: Morrow, Christopher S., et al.
Publicado: (2021)

RNA PROCESSING MECHANISMS DURING AGING AND CALORIC RESTRICTION
por: Rhoads, Timothy, et al.
Publicado: (2022)

PGC‐1a integrates a metabolism and growth network linked to caloric restriction
por: Miller, Karl N., et al.
Publicado: (2019)

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
por: Anderson, Rozalyn M, et al.
Publicado: (2008)

Rhesus monkeys as a translational model for late‐onset Alzheimer's disease
por: Souder, Dylan C., et al.
Publicado: (2021)

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
por: Dieterich, Inca A., et al.
Publicado: (2019)

PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
por: Kumar, Prakrit R., et al.
Publicado: (2022)

Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids
por: Miller, Karl N., et al.
Publicado: (2017)

Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β
por: Liesa, Marc, et al.
Publicado: (2008)

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
por: Fontecha-Barriuso, Miguel, et al.
Publicado: (2020)

PGC-1α activity and mitochondrial dysfunction in preterm infants
por: Mohammadi, Atefeh, et al.
Publicado: (2022)

PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression
por: Guak, Hannah, et al.
Publicado: (2022)

Role of PGC-1α in the Mitochondrial NAD(+) Pool in Metabolic Diseases
por: Koh, Jin-Ho, et al.
Publicado: (2021)

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism
por: Coppi, Lara, et al.
Publicado: (2021)

Pit PGC
por: CERN PhotoLab
Publicado: (1973)

PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle
por: Rowe, Glenn C., et al.
Publicado: (2012)

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis
por: LeBleu, Valerie S., et al.
Publicado: (2014)

PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
por: Dabrowska, Aleksandra, et al.
Publicado: (2015)

Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity
por: Panajatovic, M, et al.
Publicado: (2020)

HDL Mimetics Enhances Mitochondrial Function via Stimulation of PGC1-α
por: Zhang, Hang, et al.
Publicado: (2023)

Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration
por: Rigby, Michael J., et al.
Publicado: (2020)

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
por: Jiang, Haisong, et al.
Publicado: (2016)

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
por: Mäkelä, Johanna, et al.
Publicado: (2014)

Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway
por: Zhu, Zhijie, et al.
Publicado: (2022)

The PGC8 pit.
por: Jean-Luc Caron
Publicado: (1999)

The PGC8 pit.
por: Jean-Luc Caron
Publicado: (1999)

The PGC8 pit.
por: Jean-Luc Caron
Publicado: (1999)

The PGC8 pit.
por: Jean-Luc Caron
Publicado: (1999)

PGC-1β: A Regulator of Mitochondrial Function with Subtle Roles in Energy Metabolism
por: Chanut, Françoise
Publicado: (2006)

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia
por: Chen, Shang-Der, et al.
Publicado: (2011)

Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
por: Dabrowska, Aleksandra, et al.
Publicado: (2015)

Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
por: Dabrowska, Aleksandra, et al.
Publicado: (2016)

Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model
por: George, Jack, et al.
Publicado: (2019)

Regulation of Mitochondrial Proliferation by PGC-1α Induces Cellular Apoptosis in Musculoskeletal Malignancies
por: Onishi, Yasuo, et al.
Publicado: (2014)

A Role for PGC-1a in the Control of Abnormal Mitochondrial Dynamics in Alzheimer’s Disease
por: Wang, Jia, et al.
Publicado: (2022)

PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
por: Abu Shelbayeh, Othman, et al.
Publicado: (2023)

Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury
por: Yuan, Ying, et al.
Publicado: (2023)

METABOLIC INTEGRITY – A FACTOR IN AGING AND A PLAYER IN THE MECHANISMS OF CR
por: Anderson, Rozalyn
Publicado: (2019)

PROBING THE COMPLEX INTERACTIONS BETWEEN DIET, DISEASE, AND AGING
por: Anderson, Rozalyn
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0kd820tob6m79gu2ln9o48er6o