Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

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We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations....

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Detalles Bibliográficos
Autores principales: Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557820/
https://www.ncbi.nlm.nih.gov/pubmed/37808749
http://dx.doi.org/10.1101/2023.09.28.23296294
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