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Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia

BACKGROUND: Chemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML. METHODS: We d...

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Autores principales: Wu, Yuyan, Li, Mingying, Meng, Guangqiang, Ma, Yuechan, Ye, Jingjing, Sun, Tao, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557852/
https://www.ncbi.nlm.nih.gov/pubmed/37602517
http://dx.doi.org/10.1002/cam4.6468
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author Wu, Yuyan
Li, Mingying
Meng, Guangqiang
Ma, Yuechan
Ye, Jingjing
Sun, Tao
Ji, Chunyan
author_facet Wu, Yuyan
Li, Mingying
Meng, Guangqiang
Ma, Yuechan
Ye, Jingjing
Sun, Tao
Ji, Chunyan
author_sort Wu, Yuyan
collection PubMed
description BACKGROUND: Chemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML. METHODS: We detected nine single nucleotide polymorphisms (SNPs) in immune checkpoint‐related genes, including PD1, LAG3, TIM3, and TIGIT in 285 AML inpatients and 324 healthy controls. SNP genotyping was performed on the MassARRAY platform. Furthermore, we analyzed the relationship between the susceptibility and prognosis of AML and the selected SNPs. RESULTS: Our results showed that rs2227982 and rs10204525 in PD1 were significantly associated with susceptibility to AML after false discovery rate correction. PD1 rs10204525 also showed a significant correlation with the response to chemotherapy and risk stratification of AML. Importantly, the AA genotype of PD1 (rs2227982) under the recessive model showed a negative impact on AML prognosis independently. CONCLUSIONS: Our results indicate that PD1 SNPs are important for susceptibility and prognosis in AML, which may provide a new therapeutic target for AML patients.
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spelling pubmed-105578522023-10-07 Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia Wu, Yuyan Li, Mingying Meng, Guangqiang Ma, Yuechan Ye, Jingjing Sun, Tao Ji, Chunyan Cancer Med RESEARCH ARTICLES BACKGROUND: Chemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML. METHODS: We detected nine single nucleotide polymorphisms (SNPs) in immune checkpoint‐related genes, including PD1, LAG3, TIM3, and TIGIT in 285 AML inpatients and 324 healthy controls. SNP genotyping was performed on the MassARRAY platform. Furthermore, we analyzed the relationship between the susceptibility and prognosis of AML and the selected SNPs. RESULTS: Our results showed that rs2227982 and rs10204525 in PD1 were significantly associated with susceptibility to AML after false discovery rate correction. PD1 rs10204525 also showed a significant correlation with the response to chemotherapy and risk stratification of AML. Importantly, the AA genotype of PD1 (rs2227982) under the recessive model showed a negative impact on AML prognosis independently. CONCLUSIONS: Our results indicate that PD1 SNPs are important for susceptibility and prognosis in AML, which may provide a new therapeutic target for AML patients. John Wiley and Sons Inc. 2023-08-21 /pmc/articles/PMC10557852/ /pubmed/37602517 http://dx.doi.org/10.1002/cam4.6468 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Wu, Yuyan
Li, Mingying
Meng, Guangqiang
Ma, Yuechan
Ye, Jingjing
Sun, Tao
Ji, Chunyan
Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title_full Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title_fullStr Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title_full_unstemmed Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title_short Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
title_sort immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557852/
https://www.ncbi.nlm.nih.gov/pubmed/37602517
http://dx.doi.org/10.1002/cam4.6468
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