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The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China
OBJECTIVE: Our study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative‐intent surgery. METHODS: Resected GBC patients between September 2010 and January 2021 were reviewed. Comparative an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557855/ https://www.ncbi.nlm.nih.gov/pubmed/37563921 http://dx.doi.org/10.1002/cam4.6450 |
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author | Lv, Tian‐Run Liu, Fei Ma, Wen‐Jie Hu, Hai‐Jie Jin, Yan‐Wen Li, Fu‐Yu |
author_facet | Lv, Tian‐Run Liu, Fei Ma, Wen‐Jie Hu, Hai‐Jie Jin, Yan‐Wen Li, Fu‐Yu |
author_sort | Lv, Tian‐Run |
collection | PubMed |
description | OBJECTIVE: Our study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative‐intent surgery. METHODS: Resected GBC patients between September 2010 and January 2021 were reviewed. Comparative analyses between patients with CTMLD and those without it were performed. A propensity score matching analysis was conducted for further validation. RESULTS: A total of 326 resected GBC patients were identified (33 with CTMLD). A significantly higher preoperative CA199 level was detected in those with CTMLD (p = 0.0160). Significantly higher incidences of major hepatectomy (p = 0.0010), lymph node metastasis (p < 0.0001), direct liver invasion (p < 0.0001), moderate to poor differentiation status (p < 0.0001), and T3–4 disease (p < 0.0001) were detected in patients with CTMLD. Even sharing comparable surgical margin status, patients with CTMLD still shared a significantly higher recurrence rate (93.9% vs. 57.3%, p < 0.0001) as well as a significantly higher recurrence rate within 6 months after surgery (63.6% vs. 14.7%, p < 0.0001). A significantly worse overall survival (median survival time: 12 vs. 33 months, p < 0.0001) or disease‐free survival (median recurrence‐free time: 6 vs. 30 months, p < 0.0001) was acquired in patients with CTMLD. After matching, a significantly higher early recurrence rate was still detected. Adjuvant chemotherapy seemed to have survival benefit for patients with CTMLD. CONCLUSION: CTMLD was an indicator of advanced disease and served as an independent predictor of early recurrence among resected GBC patients. Whether curative‐intent surgery is superior to nonsurgical treatment among GBC patients with CTMLD remains to be explored in future prospective studies. |
format | Online Article Text |
id | pubmed-10557855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105578552023-10-07 The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China Lv, Tian‐Run Liu, Fei Ma, Wen‐Jie Hu, Hai‐Jie Jin, Yan‐Wen Li, Fu‐Yu Cancer Med RESEARCH ARTICLES OBJECTIVE: Our study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative‐intent surgery. METHODS: Resected GBC patients between September 2010 and January 2021 were reviewed. Comparative analyses between patients with CTMLD and those without it were performed. A propensity score matching analysis was conducted for further validation. RESULTS: A total of 326 resected GBC patients were identified (33 with CTMLD). A significantly higher preoperative CA199 level was detected in those with CTMLD (p = 0.0160). Significantly higher incidences of major hepatectomy (p = 0.0010), lymph node metastasis (p < 0.0001), direct liver invasion (p < 0.0001), moderate to poor differentiation status (p < 0.0001), and T3–4 disease (p < 0.0001) were detected in patients with CTMLD. Even sharing comparable surgical margin status, patients with CTMLD still shared a significantly higher recurrence rate (93.9% vs. 57.3%, p < 0.0001) as well as a significantly higher recurrence rate within 6 months after surgery (63.6% vs. 14.7%, p < 0.0001). A significantly worse overall survival (median survival time: 12 vs. 33 months, p < 0.0001) or disease‐free survival (median recurrence‐free time: 6 vs. 30 months, p < 0.0001) was acquired in patients with CTMLD. After matching, a significantly higher early recurrence rate was still detected. Adjuvant chemotherapy seemed to have survival benefit for patients with CTMLD. CONCLUSION: CTMLD was an indicator of advanced disease and served as an independent predictor of early recurrence among resected GBC patients. Whether curative‐intent surgery is superior to nonsurgical treatment among GBC patients with CTMLD remains to be explored in future prospective studies. John Wiley and Sons Inc. 2023-08-10 /pmc/articles/PMC10557855/ /pubmed/37563921 http://dx.doi.org/10.1002/cam4.6450 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Lv, Tian‐Run Liu, Fei Ma, Wen‐Jie Hu, Hai‐Jie Jin, Yan‐Wen Li, Fu‐Yu The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title | The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title_full | The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title_fullStr | The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title_full_unstemmed | The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title_short | The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China |
title_sort | significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: a 10‐year experience in china |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557855/ https://www.ncbi.nlm.nih.gov/pubmed/37563921 http://dx.doi.org/10.1002/cam4.6450 |
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