Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity

The tumor-specific chromosomal translocation product, PAX3::FOXO1, is an aberrant fusion protein that plays a key role for oncogenesis in the alveolar subtype of rhabdomyosarcoma (RMS). PAX3::FOXO1 represents a validated molecular target for alveolar RMS and successful inhibition of its oncogenic ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakazawa, Kay, Shaw, Taryn, Song, Young K., Kouassi-Brou, Marilyn, Molotkova, Anna, Tiwari, Purushottam B., Chou, Hsien-Chao, Wen, Xinyu, Wei, Jun S., Deniz, Emre, Toretsky, Jeffrey A., Keller, Charles, Barr, Frederic G., Khan, Javed, Üren, Aykut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557868/
https://www.ncbi.nlm.nih.gov/pubmed/37732905
http://dx.doi.org/10.1158/2767-9764.CRC-23-0119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557868/
https://www.ncbi.nlm.nih.gov/pubmed/37732905
http://dx.doi.org/10.1158/2767-9764.CRC-23-0119

Ejemplares similares