Cargando…

Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an effective cure. Herein, we explore the role of 3,5,3′-triiodothyronine (T(3)) administration on lung alveolar regeneration and fibrosis at the single-cell level. T(3) supplementation significantly altered...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lan, Li, Zhongzheng, Wan, Ruyan, Pan, Xin, Li, Bin, Zhao, Huabin, Yang, Juntang, Zhao, Weiming, Wang, Shenghui, Wang, Qiwen, Yan, Peishuo, Ma, Chi, Yuan, Hongmei, Zhao, Mengxia, Rosas, Ivan, Ding, Chen, Sun, Baofa, Yu, Guoying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557923/ https://www.ncbi.nlm.nih.gov/pubmed/37402274 http://dx.doi.org/10.1165/rcmb.2023-0080OC

Ejemplares similares

Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis
por: Li, Zhongzheng, et al.
Publicado: (2023)

Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence
por: Wang, Lan, et al.
Publicado: (2022)

Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis
por: Zhao, Weiming, et al.
Publicado: (2023)

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts
por: Wan, Ruyan, et al.
Publicado: (2023)

Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation
por: Wang, Lan, et al.
Publicado: (2022)

Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease
por: Zhao, Huabin, et al.
Publicado: (2023)

TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF
por: Wang, Lan, et al.
Publicado: (2022)

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia
por: Li, Zhongzheng, et al.
Publicado: (2023)

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration
por: Zhao, Weiming, et al.
Publicado: (2023)

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis
por: Yang, Juntang, et al.
Publicado: (2020)

High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters
por: Yang, Juntang, et al.
Publicado: (2023)

Cellular Senescence: A Troy Horse in Pulmonary Fibrosis
por: Wan, Ruyan, et al.
Publicado: (2023)

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
por: Yu, Guoying, et al.
Publicado: (2017)

Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones
por: Liu, Qiuhong, et al.
Publicado: (2022)

Aerosolized Thyroid Hormone Prevents Radiation Induced Lung Fibrosis
por: Li, Long, et al.
Publicado: (2020)

Corrigendum: Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones
por: Liu, Qiuhong, et al.
Publicado: (2023)

Autophagy in Idiopathic Pulmonary Fibrosis
por: Patel, Avignat S., et al.
Publicado: (2012)

Clinical significance of thyroid hormone and antibodies in patients with idiopathic interstitial pneumonia
por: Sato, Yuki, et al.
Publicado: (2020)

New Perspectives on the Aberrant Alveolar Repair of Idiopathic Pulmonary Fibrosis
por: Wang, Zhao Ni, et al.
Publicado: (2020)

Global Methylation Patterns in Idiopathic Pulmonary Fibrosis
por: Rabinovich, Einat I., et al.
Publicado: (2012)

Identification of Thyroid Hormones and Functional Characterization of Thyroid Hormone Receptor in the Pacific Oyster Crassostrea gigas Provide Insight into Evolution of the Thyroid Hormone System
por: Huang, Wen, et al.
Publicado: (2015)

Clinical observation and analysis of thyroid hormone levels in patients with idiopathic membranous nephropathy
por: Huang, Yu, et al.
Publicado: (2020)

Relation between sex hormones and leucocyte telomere length in men with idiopathic pulmonary fibrosis
por: Fang, Chuling, et al.
Publicado: (2020)

Thyroid hormone resistance syndrome due to a novel heterozygous mutation and concomitant Hashimoto’s Thyroiditis: A pedigree report
por: Xie, Zongyan, et al.
Publicado: (2022)

A novel mutation of thyroid hormone receptor β in exon 10 in a case of thyroid hormone-resistant non-Hodgkin’s lymphoma of the thyroid
por: CHEN, KE, et al.
Publicado: (2015)

Genes related to N6-methyladenosine in the diagnosis and prognosis of idiopathic pulmonary fibrosis
por: Zhang, Jingcheng, et al.
Publicado: (2023)

Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis
por: Zhao, Tianming, et al.
Publicado: (2023)

Correlation analysis of serum thyroglobulin, thyroid-stimulating hormone levels, and thyroid-cancer risk in thyroid nodule surgery
por: Shuai, Jin-Hao, et al.
Publicado: (2023)

Decreased absolute number of peripheral regulatory T cells in patients with idiopathic retroperitoneal fibrosis
por: Liu, Lu, et al.
Publicado: (2022)

Idiopathic Retroperitoneal Fibrosis Associated with Hashimoto's Thyroiditis in an Old-aged Man
por: Lee, Jung Eun, et al.
Publicado: (2008)

A Rare Co-association of Autoimmune Thyroiditis and Idiopathic Retroperitoneal Fibrosis
por: Adhikari, Ramesh, et al.
Publicado: (2022)

Oncogenic mutations of thyroid hormone receptor β
por: Park, Jeong Won, et al.
Publicado: (2015)

Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis
por: Zhang, Yanan, et al.
Publicado: (2021)

Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?
por: Chen, Yi, et al.
Publicado: (2018)

Pituitary resistance to thyroid hormone caused by a novel mutation (H435A) in the thyroid hormone receptor beta: A case report
por: Yu, Changzhen, et al.
Publicado: (2018)

The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
por: Weng, Dong, et al.
Publicado: (2019)

Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study
por: Zhao, Yidan D, et al.
Publicado: (2017)

Thyroid hormone resistance syndrome caused by heterozygous A317T mutation in thyroid hormone receptor β gene: Report of one Chinese pedigree and review of the literature
por: Guo, Qing-Hua, et al.
Publicado: (2016)

Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation
por: Wang, Xiaolei, et al.
Publicado: (2020)

Neutrophil-Related Gene Expression Signatures in Idiopathic Pulmonary Fibrosis: Implications for Disease Characteristic and Identification of Diagnostic Hub Genes
por: Lin, Yingying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0te7q2vkajr92m52rca8s8jdjf